PMID- 22563866
OWN - NLM
STAT- MEDLINE
DCOM- 20130312
LR  - 20121005
IS  - 1365-2265 (Electronic)
IS  - 0300-0664 (Linking)
VI  - 77
IP  - 5
DP  - 2012 Nov
TI  - Plasma brain-derived neurotrophic factor in prepubertal obese children: results 
      from a 2-year lifestyle intervention programme.
PG  - 715-20
LID - 10.1111/j.1365-2265.2012.04431.x [doi]
AB  - CONTEXT: Brain-derived neurotrophic factor (BDNF) is a neurotrophin potentially 
      involved in the pathophysiology of obesity and metabolic syndrome in adults. In 
      children, it has scarcely been studied. OBJECTIVE: To analyse plasma BDNF and its 
      relationship with metabolic syndrome components before and after 2 years of a 
      lifestyle intervention programme in a prepubertal obese cohort. DESIGN AND 
      SETTING: Case-control study with a 2-year prospective follow-up in a referral 
      paediatric endocrine outpatient centre. PATIENTS AND METHODS: Seventy-three 
      prepubertal obese children, 8.03 +/- 1.08 years old, and 47 age- and gender-matched 
      lean controls were studied. Anthropometric parameters, blood pressure, platelet 
      count (PLT), oral glucose tolerance test, homoeostatic model assessment for 
      insulin resistance (HOMA-IR), lipid profile, BDNF, diet and physical activity 
      were evaluated. Weight loss was considered if z-score body mass index (BMI) 
      decreased at least 0.5 SD. RESULTS: At baseline, BDNF tended to be lower in 
      prepubertal obese children compared with lean controls (P = 0.076). BDNF did not 
      correlate with any metabolic syndrome component. After 2 years, obese patients 
      showed an increase in BDNF. Regression model analysis adjusted by age, sex, 
      puberty, BMI, PLT and HOMA-IR showed that BDNF increased in subjects who lost 
      weight (P = 0.036), practiced sports (P = 0.008) and had an adequate carbohydrate 
      intake (P = 0.032). CONCLUSIONS: Plasma BDNF tends to be lower in obese 
      prepubertal children than in lean controls, is not related to any other metabolic 
      syndrome component and increases after a lifestyle intervention programme.
CI  - (c) 2012 Blackwell Publishing Ltd.
FAU - Corripio, Raquel
AU  - Corripio R
AD  - Department of Paediatric Endocrine, Sabadell Hospital, Parc Tauli Corporation, 
      University Autonomous of Barcelona, Sabadell, Spain.
FAU - Gonzalez-Clemente, Jose-Miguel
AU  - Gonzalez-Clemente JM
FAU - Jacobo, Perez-Sanchez
AU  - Jacobo PS
FAU - Silvia, Naf
AU  - Silvia N
FAU - Lluis, Gallart
AU  - Lluis G
FAU - Joan, Vendrell
AU  - Joan V
FAU - Assumpta, Caixas
AU  - Assumpta C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Clin Endocrinol (Oxf)
JT  - Clinical endocrinology
JID - 0346653
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Humans
MH  - Male
MH  - Obesity/*blood
MH  - Prospective Studies
MH  - Risk Reduction Behavior
EDAT- 2012/05/09 06:00
MHDA- 2013/03/13 06:00
CRDT- 2012/05/09 06:00
PHST- 2012/05/09 06:00 [entrez]
PHST- 2012/05/09 06:00 [pubmed]
PHST- 2013/03/13 06:00 [medline]
AID - 10.1111/j.1365-2265.2012.04431.x [doi]
PST - ppublish
SO  - Clin Endocrinol (Oxf). 2012 Nov;77(5):715-20. doi: 
      10.1111/j.1365-2265.2012.04431.x.