PMID- 22563929
OWN - NLM
STAT- MEDLINE
DCOM- 20130114
LR  - 20120820
IS  - 1537-6524 (Electronic)
IS  - 1537-6516 (Linking)
VI  - 22
IP  - 7
DP  - 2012 Sep
TI  - Is cardiac tissue more susceptible than lung to oxidative effects induced by 
      chronic nasotropic instillation of residual oil fly ash (ROFA)?
PG  - 533-9
LID - 10.3109/15376516.2012.692109 [doi]
AB  - The current study aimed to determine the role of oxidants in cardiac and 
      pulmonary toxicities induced by chronic exposure to ROFA. Eighty Wistar rats were 
      divided into four groups: G1 (10 microL Saline), G2 (ROFA 50 microg/10 microL), G3 (ROFA 250 
      microg/10 microL) and G4 (ROFA 500 microg/10 microL). Rats received ROFA by nasotropic 
      instillation for 90 days. After that, they were euthanized and bronchoalveolar 
      lavage (BAL) was performed for total count of leukocytes, protein and lactate 
      dehydrogenase (LDH) determinations. Lungs and heart were removed to measure lipid 
      peroxidation (MDA), catalase (CAT) and superoxide dismutase (SOD) activity. BAL 
      presented an increase in leukocytes count in G4 in comparison to the Saline group 
      (p = 0.019). In lung, MDA level was not modified by ROFA, while CAT was higher in 
      G4 when compared to all other groups (p = 0.013). In heart, G4 presented an 
      increase in MDA (p = 0.016) and CAT (p = 0.027) levels in comparison to G1. The 
      present study demonstrated cardiopulmonary oxidative changes after a chronic ROFA 
      exposure. More specifically, the heart tissue seems to be more susceptible to 
      oxidative effects of long-term exposure to ROFA than the lung.
FAU - Damiani, Roberto Marques
AU  - Damiani RM
AD  - Laboratorio de Estresse Oxidativo e Poluicao Atmosferica, Universidade Federal de 
      Ciencias da Saude de Porto Alegre, Brasil. marquesdamiani@gmail.com
FAU - Piva, Marcella Ody
AU  - Piva MO
FAU - Petry, Marcelo Rafael
AU  - Petry MR
FAU - Saldiva, Paulo Hilario Nascimento
AU  - Saldiva PH
FAU - Tavares Duarte de Oliveira, Alexandre
AU  - Tavares Duarte de Oliveira A
FAU - Rhoden, Claudia Ramos
AU  - Rhoden CR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120530
PL  - England
TA  - Toxicol Mech Methods
JT  - Toxicology mechanisms and methods
JID - 101134521
RN  - 0 (Air Pollutants)
RN  - 0 (Coal Ash)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Air Pollutants/*toxicity
MH  - Animals
MH  - Bronchoalveolar Lavage Fluid/chemistry
MH  - Catalase/metabolism
MH  - Coal Ash/*toxicity
MH  - Data Interpretation, Statistical
MH  - Dose-Response Relationship, Drug
MH  - Heart/*drug effects
MH  - Instillation, Drug
MH  - Leukocyte Count
MH  - Lipid Peroxidation/drug effects
MH  - Lung/*drug effects/enzymology/metabolism
MH  - Male
MH  - Myocardium/enzymology/metabolism
MH  - Oxidative Stress/*drug effects
MH  - Pneumonia/chemically induced/enzymology
MH  - Rats
MH  - Rats, Wistar
MH  - Superoxide Dismutase/metabolism
MH  - Toxicity Tests, Chronic
EDAT- 2012/05/09 06:00
MHDA- 2013/01/15 06:00
CRDT- 2012/05/09 06:00
PHST- 2012/05/09 06:00 [entrez]
PHST- 2012/05/09 06:00 [pubmed]
PHST- 2013/01/15 06:00 [medline]
AID - 10.3109/15376516.2012.692109 [doi]
PST - ppublish
SO  - Toxicol Mech Methods. 2012 Sep;22(7):533-9. doi: 10.3109/15376516.2012.692109. 
      Epub 2012 May 30.