PMID- 22564191
OWN - NLM
STAT- MEDLINE
DCOM- 20121113
LR  - 20211021
IS  - 1600-0897 (Electronic)
IS  - 1046-7408 (Print)
IS  - 1046-7408 (Linking)
VI  - 68
IP  - 2
DP  - 2012 Aug
TI  - Toll-like receptor 4 expression in decidual cells and interstitial trophoblasts 
      across human pregnancy.
PG  - 146-53
LID - 10.1111/j.1600-0897.2012.01148.x [doi]
AB  - PROBLEM: Toll-like receptor-4 (TLR-4) protects against Gram-negative bacteria 
      expressed lipopolysaccharide and 'danger signals' from injured or dying cells. 
      Although decidual cells (DCs) and interstitial trophoblasts (ITs) are in close 
      contact, TLR-4 has been studied extensively only in ITs. METHOD OF STUDY: 
      Formalin-fixed, paraffin-embedded serial sections of endometrium in follicular 
      and luteal phases and deciduas from first and second trimester elective 
      terminations and third trimester normal deliveries were immunostained for TLR-4, 
      trophoblast-specific cytokeratin, and DC-specific vimentin. HSCORE assessed TLR-4 
      immunostaining in DCs versus ITs. RESULTS: TLR-4 HSCORES were significantly 
      higher in: (i) first trimester DCs than luteal phase pre-decidual stromal cells; 
      (ii) first and third versus second trimester DCs, but similar between third 
      trimester deciduas parietalis and basalis; (iii) first versus second trimester 
      ITs; (iv) DCs versus ITs across gestation. CONCLUSION: Higher TLR-4 in DCs than 
      ITs suggests DCs as primary targets for Gram-negative bacteria and/or 
      inflammation-related danger signals.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Schatz, Frederic
AU  - Schatz F
AD  - Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University 
      School of Medicine, New Haven, CT, USA. Frederick.Schatz@osumc.edu
FAU - Kayisli, Umit A
AU  - Kayisli UA
FAU - Vatandaslar, Emre
AU  - Vatandaslar E
FAU - Ocak, Nehir
AU  - Ocak N
FAU - Guller, Seth
AU  - Guller S
FAU - Abrahams, Vikki M
AU  - Abrahams VM
FAU - Krikun, Graciela
AU  - Krikun G
FAU - Lockwood, Charles J
AU  - Lockwood CJ
LA  - eng
GR  - P01 HD054713/HD/NICHD NIH HHS/United States
GR  - P01 HD054713-01A2/HD/NICHD NIH HHS/United States
GR  - HD054713-01A1/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120508
PL  - Denmark
TA  - Am J Reprod Immunol
JT  - American journal of reproductive immunology (New York, N.Y. : 1989)
JID - 8912860
RN  - 0 (Biomarkers)
RN  - 0 (Keratin-7)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Vimentin)
SB  - IM
MH  - Biomarkers/metabolism
MH  - Decidua/*immunology/pathology
MH  - Female
MH  - Follicular Phase/immunology
MH  - Gene Expression Regulation, Developmental
MH  - Humans
MH  - Immunohistochemistry
MH  - Keratin-7/genetics/metabolism
MH  - Luteal Phase/immunology
MH  - Pregnancy
MH  - Premature Birth/*immunology
MH  - Toll-Like Receptor 4/genetics/*metabolism
MH  - Trophoblasts/*immunology
MH  - Up-Regulation
MH  - Vimentin/genetics/metabolism
PMC - PMC3395732
MID - NIHMS368415
EDAT- 2012/05/09 06:00
MHDA- 2012/11/14 06:00
PMCR- 2013/08/01
CRDT- 2012/05/09 06:00
PHST- 2012/02/16 00:00 [received]
PHST- 2012/03/29 00:00 [accepted]
PHST- 2012/05/09 06:00 [entrez]
PHST- 2012/05/09 06:00 [pubmed]
PHST- 2012/11/14 06:00 [medline]
PHST- 2013/08/01 00:00 [pmc-release]
AID - 10.1111/j.1600-0897.2012.01148.x [doi]
PST - ppublish
SO  - Am J Reprod Immunol. 2012 Aug;68(2):146-53. doi: 
      10.1111/j.1600-0897.2012.01148.x. Epub 2012 May 8.