PMID- 22565056
OWN - NLM
STAT- MEDLINE
DCOM- 20121001
LR  - 20131121
IS  - 1090-2163 (Electronic)
IS  - 0008-8749 (Linking)
VI  - 276
IP  - 1-2
DP  - 2012 Mar-Apr
TI  - Distinct modulation of chemokine expression patterns in human monocyte-derived 
      dendritic cells by prostaglandin E(2).
PG  - 52-8
LID - 10.1016/j.cellimm.2012.03.008 [doi]
AB  - Dendritic cells (DCs) are key in regulating immune responses. DCs reside in 
      tissues facing the environment and sample their surrounding for pathogens. Upon 
      pathogen encounter, DCs mature and migrate into secondary lymphoid organs. 
      Distinct maturation signals dictate the ability of DCs to produce distinct 
      patterns of chemokines that orchestrate immunity. Prostaglandin E(2) (PGE(2)) is 
      produced during inflammation and modulates DC functions. We demonstrate that 
      PGE(2) modulates distinct chemokine expression patterns of human monocyte-derived 
      (Mo) DCs upon maturation with various stimuli. PGE(2) dampened early production 
      of the inflammatory chemokines CCL2, CCL4, CCL5 and attenuated the expression of 
      the T cell attractant CXCL10. In contrast, PGE(2) enhanced CXCL8 production early 
      during maturation, whereas CXCL16 levels were continuously elevated, contributing 
      to innate immune cell recruitment. Moreover, PGE(2) induces transcription of the 
      homeostatic chemokines CCL17 and CCL22. Finally, mature MoDCs produced the homing 
      chemokine CCL19 and its expression was down-regulated by PGE(2).
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - Bruckner, Markus
AU  - Bruckner M
AD  - Biotechnology Institute Thurgau at the University of Konstanz, Kreuzlingen, 
      Switzerland.
FAU - Dickel, Denise
AU  - Dickel D
FAU - Singer, Eva
AU  - Singer E
FAU - Legler, Daniel F
AU  - Legler DF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120404
PL  - Netherlands
TA  - Cell Immunol
JT  - Cellular immunology
JID - 1246405
RN  - 0 (Chemokines)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - Cell Differentiation
MH  - Cells, Cultured
MH  - Chemokines/biosynthesis/genetics/*immunology
MH  - Dendritic Cells/cytology/*immunology
MH  - Dinoprostone/*immunology
MH  - Humans
MH  - Monocytes/cytology/immunology
MH  - Transcription, Genetic
EDAT- 2012/05/09 06:00
MHDA- 2012/10/02 06:00
CRDT- 2012/05/09 06:00
PHST- 2011/12/14 00:00 [received]
PHST- 2012/03/02 00:00 [revised]
PHST- 2012/03/29 00:00 [accepted]
PHST- 2012/05/09 06:00 [entrez]
PHST- 2012/05/09 06:00 [pubmed]
PHST- 2012/10/02 06:00 [medline]
AID - S0008-8749(12)00058-5 [pii]
AID - 10.1016/j.cellimm.2012.03.008 [doi]
PST - ppublish
SO  - Cell Immunol. 2012 Mar-Apr;276(1-2):52-8. doi: 10.1016/j.cellimm.2012.03.008. 
      Epub 2012 Apr 4.