PMID- 2256585
OWN - NLM
STAT- MEDLINE
DCOM- 19910124
LR  - 20041117
IS  - 0003-410X (Print)
IS  - 0003-410X (Linking)
VI  - 141
IP  - 5
DP  - 1990
TI  - Subacute cutaneous lupus erythematosus in Greece. A clinical, serological and 
      genetic study.
PG  - 421-4
AB  - We present herein clinical, serological and genetic findings on 27 Greek, 
      subacute cutaneous lupus erythematosus (SCLE) patients. Twenty-three (85 p. 100) 
      presented with a psoriasifom rash in a photosensitive distribution. Two patients 
      (7.5 p. 100) had an annular rash in a polycyclic pattern. Two other patients 
      exhibited both types of lesions. The majority of our patients also had other skin 
      manifestations, including butterfly rash, discoid lesions and maculopapular rash. 
      Systemic manifestations were: arthralgias or arthritis in 50 p. 100, low grade 
      fever in 35 p. 100, central nervous system involvement in 15 p. 100, Sjogren's 
      syndrome in 18 p. 100 and serositis in 8 p. 100. Anti-nuclear antibodies were 
      found in 93 p. 100; antibodies to Ro (SSA) and/or La (SSB) in 70 p. 100. 
      Twenty-one (78 p. 100) satisfied the ARA criteria for systemic lupus 
      erythematosus (SLE). No HLA-DR3 antigen association was found in the 16 patients 
      tested. These findings are somewhat different from those reported previously: a) 
      the frequency of the psoriasiform rash rather than the annular one is the highest 
      in Greek SCLE patients; b) most patients also have other skin manifestations 
      mimicking the full spectrum of SLE with prominent cutaneous lesions; and c) no 
      HLA-DR3 antigen association was found in Greek patients. Environmental, ethnic or 
      genetic factors may be responsible for these differences.
FAU - Drosos, A A
AU  - Drosos AA
AD  - Department of Internal Medicine, Medical School, University of Ioannina, Greece.
FAU - Dimou, G S
AU  - Dimou GS
FAU - Siamopoulou-Mavridou, A
AU  - Siamopoulou-Mavridou A
FAU - Hatzis, J
AU  - Hatzis J
FAU - Moutsopoulos, H M
AU  - Moutsopoulos HM
LA  - eng
PT  - Journal Article
PL  - France
TA  - Ann Med Interne (Paris)
JT  - Annales de medecine interne
JID - 0171744
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DR3 Antigen)
SB  - IM
MH  - Adult
MH  - Antibodies, Antinuclear/analysis
MH  - Autoantibodies/*analysis
MH  - Female
MH  - Greece/epidemiology
MH  - HLA-DR3 Antigen/analysis
MH  - Humans
MH  - Joint Diseases/etiology
MH  - Lupus Erythematosus, Cutaneous/*epidemiology/genetics/immunology
MH  - Male
MH  - Middle Aged
MH  - Photosensitivity Disorders/etiology
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
PST - ppublish
SO  - Ann Med Interne (Paris). 1990;141(5):421-4.