PMID- 22566224
OWN - NLM
STAT- MEDLINE
DCOM- 20120724
LR  - 20120508
IS  - 0171-2004 (Print)
IS  - 0171-2004 (Linking)
IP  - 207
DP  - 2012
TI  - Low-molecular-weight heparins: differential characterization/physical 
      characterization.
PG  - 127-57
LID - 10.1007/978-3-642-23056-1_7 [doi]
AB  - Low-molecular-weight heparins (LMWHs), derived from unfractionated heparin (UFH) 
      through different depolymerization processes, have advantages with respect to the 
      parent heparin in terms of pharmacokinetics, convenience of administration, and 
      reduced side effects. Each LMWH can be considered as an independent drug with its 
      own activity profile, placing significance on their biophysical characterization, 
      which will also enable a better understanding of their structure-function 
      relationship. Several chemical and physical methods, some involving sample 
      modification, are now available and are reviewed.
FAU - Guerrini, Marco
AU  - Guerrini M
AD  - Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, Milan, Italy. 
      guerrini@ronzoni.it
FAU - Bisio, Antonella
AU  - Bisio A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Germany
TA  - Handb Exp Pharmacol
JT  - Handbook of experimental pharmacology
JID - 7902231
RN  - 0 (Heparin, Low-Molecular-Weight)
SB  - IM
MH  - Chromatography, Liquid
MH  - Electrophoresis, Capillary
MH  - Electrophoresis, Polyacrylamide Gel
MH  - Heparin, Low-Molecular-Weight/*chemistry
MH  - Magnetic Resonance Spectroscopy
MH  - Mass Spectrometry
EDAT- 2012/05/09 06:00
MHDA- 2012/07/25 06:00
CRDT- 2012/05/09 06:00
PHST- 2012/05/09 06:00 [entrez]
PHST- 2012/05/09 06:00 [pubmed]
PHST- 2012/07/25 06:00 [medline]
AID - 10.1007/978-3-642-23056-1_7 [doi]
PST - ppublish
SO  - Handb Exp Pharmacol. 2012;(207):127-57. doi: 10.1007/978-3-642-23056-1_7.