PMID- 22566226
OWN - NLM
STAT- MEDLINE
DCOM- 20120724
LR  - 20120508
IS  - 0171-2004 (Print)
IS  - 0171-2004 (Linking)
IP  - 207
DP  - 2012
TI  - Heparin in the prophylaxis and treatment of venous thromboembolism and other 
      thrombotic diseases.
PG  - 179-209
LID - 10.1007/978-3-642-23056-1_9 [doi]
AB  - In this chapter, we discuss the key-role of heparin in the prophylaxis and 
      treatment of venous thromboembolism (VTE) and other thrombotic disorders. Heparin 
      exerts its antithrombotic effects by facilitating the ability of antithrombin 
      (AT), a plasma serum protease inhibitor, to inhibit thrombin (factor IIa) and 
      factor Xa. Different heparin formulations can be used for the prophylaxis of 
      thrombosis and treatment, going from unfractionated heparin (UFH), different 
      low-molecular-weight heparin (LMWH) preparations, to the recently introduced 
      synthetic pentasaccharide fondaparinux. All heparin formulations can be 
      administrated only by the parenteral route, including the intravenous (iv) and 
      the subcutaneous (sc) route. We will overview the clinical evidence for the use 
      of different heparin formulations in the prophylaxis and treatment of venous 
      thromboembolism, of superficial vein thrombosis and of acute coronary syndromes 
      (ACS). Special issues, like the use of heparins in pregnancy or in children, will 
      also be discussed. Although heparin is an almost one century-old drug it remains 
      a cornerstone of antithrombotic treatment.
FAU - Gresele, Paolo
AU  - Gresele P
AD  - Department of Internal Medicine, University of Perugia, Perugia, Italy. 
      grespa@unipg.it
FAU - Busti, Chiara
AU  - Busti C
FAU - Paganelli, Gloria
AU  - Paganelli G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Germany
TA  - Handb Exp Pharmacol
JT  - Handbook of experimental pharmacology
JID - 7902231
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Acute Coronary Syndrome/*drug therapy
MH  - Child
MH  - Female
MH  - Heparin/*therapeutic use
MH  - Humans
MH  - Pregnancy
MH  - Pregnancy Complications, Hematologic/*drug therapy
MH  - Venous Thromboembolism/complications/*drug therapy/*prevention & control
EDAT- 2012/05/09 06:00
MHDA- 2012/07/25 06:00
CRDT- 2012/05/09 06:00
PHST- 2012/05/09 06:00 [entrez]
PHST- 2012/05/09 06:00 [pubmed]
PHST- 2012/07/25 06:00 [medline]
AID - 10.1007/978-3-642-23056-1_9 [doi]
PST - ppublish
SO  - Handb Exp Pharmacol. 2012;(207):179-209. doi: 10.1007/978-3-642-23056-1_9.