PMID- 22566821
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 2
DP  - 2011
TI  - Chemokines: a new dendritic cell signal for T cell activation.
PG  - 31
LID - 10.3389/fimmu.2011.00031 [doi]
LID - 31
AB  - Dendritic cells (DCs) are the main inducers and regulators of cytotoxic T 
      lymphocyte (CTL) responses against viruses and tumors. One checkpoint to avoid 
      misguided CTL activation, which might damage healthy cells of the body, is the 
      necessity for multiple activation signals, involving both antigenic as well as 
      additional signals that reflect the presence of pathogens. DCs provide both 
      signals when activated by ligands of pattern recognition receptors and "licensed" 
      by helper lymphocytes. Recently, it has been established that such T cell 
      licensing can be facilitated by CD4(+) T helper cells ("classical licensing") or by 
      natural killer T cells ("alternative licensing"). Licensing regulates the DC/CTL 
      cross-talk at multiple layers. Direct recruitment of CTLs through chemokines 
      released by licensed DCs has recently emerged as a common theme and has a crucial 
      impact on the efficiency of CTL responses. Here, we discuss recent advances in 
      our understanding of DC licensing for cross-priming and implications for the 
      temporal and spatial regulation underlying this process. Future vaccination 
      strategies will benefit from a deeper insight into the mechanisms that govern CTL 
      activation.
FAU - Thaiss, Christoph A
AU  - Thaiss CA
AD  - Institutes of Molecular Medicine and Experimental Immunology, Rheinische 
      Friedrich-Wilhelms-University Bonn, Germany.
FAU - Semmling, Verena
AU  - Semmling V
FAU - Franken, Lars
AU  - Franken L
FAU - Wagner, Hermann
AU  - Wagner H
FAU - Kurts, Christian
AU  - Kurts C
LA  - eng
PT  - Journal Article
DEP - 20110801
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC3342358
OTO - NOTNLM
OT  - NKT cells
OT  - T cell activation
OT  - antigen presentation
OT  - chemokines
OT  - costimulation
OT  - dendritic cells
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
PMCR- 2011/01/01
CRDT- 2012/05/09 06:00
PHST- 2011/06/13 00:00 [received]
PHST- 2011/07/20 00:00 [accepted]
PHST- 2012/05/09 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PHST- 2011/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2011.00031 [doi]
PST - epublish
SO  - Front Immunol. 2011 Aug 1;2:31. doi: 10.3389/fimmu.2011.00031. eCollection 2011.