PMID- 22566910
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 3
DP  - 2012
TI  - Transcriptional regulation of dendritic cell diversity.
PG  - 26
LID - 10.3389/fimmu.2012.00026 [doi]
LID - 26
AB  - Dendritic cells (DCs) are specialized antigen presenting cells that are 
      exquisitely adapted to sense pathogens and induce the development of adaptive 
      immune responses. They form a complex network of phenotypically and functionally 
      distinct subsets. Within this network, individual DC subsets display highly 
      specific roles in local immunosurveillance, migration, and antigen presentation. 
      This division of labor amongst DCs offers great potential to tune the immune 
      response by harnessing subset-specific attributes of DCs in the clinical setting. 
      Until recently, our understanding of DC subsets has been limited and paralleled 
      by poor clinical translation and efficacy. We have now begun to unravel how 
      different DC subsets develop within a complex multilayered system. These findings 
      open up exciting possibilities for targeted manipulation of DC subsets. 
      Furthermore, ground-breaking developments overcoming a major translational 
      obstacle - identification of similar DC populations in mouse and man - now sets 
      the stage for significant advances in the field. Here we explore the determinants 
      that underpin cellular and transcriptional heterogeneity within the DC network, 
      how these influence DC distribution and localization at steady-state, and the 
      capacity of DCs to present antigens via direct or cross-presentation during 
      pathogen infection.
FAU - Chopin, Michael
AU  - Chopin M
AD  - Division of Molecular Immunology, The Walter and Eliza Hall Institute of Medical 
      Research Melbourne, VIC, Australia.
FAU - Allan, Rhys S
AU  - Allan RS
FAU - Belz, Gabrielle T
AU  - Belz GT
LA  - eng
PT  - Journal Article
DEP - 20120227
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC3341959
OTO - NOTNLM
OT  - dendritic cells
OT  - differentiation
OT  - immunity
OT  - transcription factors
EDAT- 2012/05/09 06:00
MHDA- 2012/05/09 06:01
PMCR- 2012/01/01
CRDT- 2012/05/09 06:00
PHST- 2011/12/05 00:00 [received]
PHST- 2012/02/08 00:00 [accepted]
PHST- 2012/05/09 06:00 [entrez]
PHST- 2012/05/09 06:00 [pubmed]
PHST- 2012/05/09 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2012.00026 [doi]
PST - epublish
SO  - Front Immunol. 2012 Feb 27;3:26. doi: 10.3389/fimmu.2012.00026. eCollection 2012.