PMID- 22566940
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 3
DP  - 2012
TI  - Pattern Recognition Receptors in HIV Transmission.
PG  - 59
LID - 10.3389/fimmu.2012.00059 [doi]
LID - 59
AB  - Dendritic cells (DCs), Langerhans cells (LCs), and macrophages are innate immune 
      cells that reside in genital and intestinal mucosal tissues susceptible to HIV-1 
      infection. These innate cells play distinct roles in initiation of HIV-1 
      infection and induction of anti-viral immunity. DCs are potent migratory cells 
      that capture HIV-1 and transfer virus to CD4(+) T cells in the lymph nodes, 
      whereas LCs have a protective anti-viral function, and macrophages function as 
      viral reservoirs since they produce viruses over prolonged times. These 
      differences are due to the different immune functions of these cells partly 
      dependent on the expression of specific pattern recognition receptors. Expression 
      of Toll-like receptors, C-type lectin receptors, and cell-specific machinery for 
      antigen uptake and processing strongly influence the outcome of virus 
      interactions.
FAU - Mesman, Annelies W
AU  - Mesman AW
AD  - Department for Experimental Immunology, Academic Medical Center, University of 
      Amsterdam Amsterdam, Netherlands.
FAU - Geijtenbeek, Teunis B
AU  - Geijtenbeek TB
LA  - eng
PT  - Journal Article
DEP - 20120326
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
PMC - PMC3341947
OTO - NOTNLM
OT  - HIV transmission
OT  - innate immunity
EDAT- 2012/05/09 06:00
MHDA- 2012/05/09 06:01
PMCR- 2012/01/01
CRDT- 2012/05/09 06:00
PHST- 2011/12/20 00:00 [received]
PHST- 2012/03/07 00:00 [accepted]
PHST- 2012/05/09 06:00 [entrez]
PHST- 2012/05/09 06:00 [pubmed]
PHST- 2012/05/09 06:01 [medline]
PHST- 2012/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2012.00059 [doi]
PST - epublish
SO  - Front Immunol. 2012 Mar 26;3:59. doi: 10.3389/fimmu.2012.00059. eCollection 2012.