PMID- 22567368
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20211021
IS  - 2090-3162 (Electronic)
IS  - 2090-3154 (Print)
IS  - 2090-3162 (Linking)
VI  - 2011
DP  - 2011
TI  - Genetic markers used for risk stratification in multiple myeloma.
PG  - 798089
LID - 10.4061/2011/798089 [doi]
LID - 798089
AB  - While no specific genetic markers are required in the diagnosis of multiple 
      myeloma (MM), multiple genetic abnormalities and gene signatures are used in 
      disease prognostication and risk stratification. This is particularly important 
      for the adequate identification of the high-risk MM group, which does not benefit 
      from any of the current therapies, and novel approaches need to be proposed. 
      Fluorescence in situ hybridization (FISH) has been employed for establishing 
      risk-based stratification and still remains the most used genetic technique in 
      the clinical routine. The incorporation of gene expression profiling (GEP) in the 
      study of MM has shown to be a very powerful test in the patient stratification, 
      but its incorporation in clinical routine depends on some technical and logistic 
      resolutions. Thus, FISH still remains the gold standard test for detecting 
      genomic abnormalities and outcome discrimination in MM.
FAU - Segges, Priscilla
AU  - Segges P
AD  - Laboratory of Molecular Biology, Bone Marrow Transplantation Center, National 
      Cancer Institute, Rio de Janeiro, RJ 20230-130, Brazil.
FAU - Braggio, Esteban
AU  - Braggio E
LA  - eng
PT  - Journal Article
DEP - 20110913
PL  - Egypt
TA  - Genet Res Int
JT  - Genetics research international
JID - 101571472
PMC - PMC3335595
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
PMCR- 2011/09/13
CRDT- 2012/05/09 06:00
PHST- 2011/05/31 00:00 [received]
PHST- 2011/07/14 00:00 [accepted]
PHST- 2012/05/09 06:00 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
PHST- 2011/09/13 00:00 [pmc-release]
AID - 10.4061/2011/798089 [doi]
PST - ppublish
SO  - Genet Res Int. 2011;2011:798089. doi: 10.4061/2011/798089. Epub 2011 Sep 13.