PMID- 22568593
OWN - NLM
STAT- MEDLINE
DCOM- 20121226
LR  - 20240406
IS  - 1600-6143 (Electronic)
IS  - 1600-6135 (Print)
IS  - 1600-6135 (Linking)
VI  - 12
IP  - 8
DP  - 2012 Aug
TI  - Antibodies to K-alpha 1 tubulin and collagen V are associated with chronic rejection 
      after lung transplantation.
PG  - 2164-71
LID - 10.1111/j.1600-6143.2012.04079.x [doi]
AB  - Bronchiolitis obliterans syndrome (BOS), the clinical correlate of chronic 
      rejection after lung transplantation, is the leading obstacle to better long-term 
      outcomes. We previously instituted a clinical protocol to screen for 
      donor-specific human leukocyte antigen (HLA) antibodies (DSA) and a preemptive 
      antibody-directed therapy protocol consisting of rituximab and/or intravenous 
      immune globulin. In this study, we retrospectively analyzed serum samples from 
      lung transplant recipients (n = 108) for antibodies to self-antigens (K-alpha 1 
      tubulin and collagen V) before and after antibody-directed therapy and correlated 
      the results with the subsequent development of BOS. Seventy-two of the 108 
      recipients developed antibodies to self-antigens. There was a correlation between 
      the development of antibodies to self-antigens and DSA. Sixteen of the 54 
      patients who had antibodies to self-antigens and were treated with 
      antibody-directed therapy cleared the antibodies, and they were significantly 
      less likely to develop BOS than those who had persistent antibodies. Furthermore, 
      those who cleared DSA after treatment but had persistent antibodies to 
      self-antigens were significantly more likely to develop BOS than those who 
      cleared these antibodies. We conclude that antibodies to self-antigens are an 
      important risk factor for the development of BOS.
CI  - (c) Copyright 2012 The American Society of Transplantation and the American Society 
      of Transplant Surgeons.
FAU - Hachem, R R
AU  - Hachem RR
AD  - Division of Pulmonary & Critical Care Medicine, Washington University School of 
      Medicine in St. Louis, St. Louis, MO, USA. rhachem@dom.wustl.edu
FAU - Tiriveedhi, V
AU  - Tiriveedhi V
FAU - Patterson, G A
AU  - Patterson GA
FAU - Aloush, A
AU  - Aloush A
FAU - Trulock, E P
AU  - Trulock EP
FAU - Mohanakumar, T
AU  - Mohanakumar T
LA  - eng
GR  - R01 HL056643/HL/NHLBI NIH HHS/United States
GR  - R01 HL056643-13A1/HL/NHLBI NIH HHS/United States
GR  - R34 HL105412/HL/NHLBI NIH HHS/United States
GR  - R34 HL105412-02/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120508
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (Autoantibodies)
RN  - 0 (Autoantigens)
RN  - 0 (Collagen Type V)
RN  - 0 (Tubulin)
SB  - IM
MH  - Adult
MH  - Autoantibodies/*immunology
MH  - Autoantigens/immunology
MH  - Bronchiolitis Obliterans/immunology
MH  - Collagen Type V/*immunology
MH  - Female
MH  - *Graft Rejection
MH  - Humans
MH  - *Lung Transplantation
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Tubulin/*immunology
PMC - PMC3409301
MID - NIHMS367542
EDAT- 2012/05/10 06:00
MHDA- 2012/12/27 06:00
PMCR- 2013/08/01
CRDT- 2012/05/10 06:00
PHST- 2012/05/10 06:00 [entrez]
PHST- 2012/05/10 06:00 [pubmed]
PHST- 2012/12/27 06:00 [medline]
PHST- 2013/08/01 00:00 [pmc-release]
AID - S1600-6135(22)27574-1 [pii]
AID - 10.1111/j.1600-6143.2012.04079.x [doi]
PST - ppublish
SO  - Am J Transplant. 2012 Aug;12(8):2164-71. doi: 10.1111/j.1600-6143.2012.04079.x. 
      Epub 2012 May 8.