PMID- 22569815
OWN - NLM
STAT- MEDLINE
DCOM- 20130204
LR  - 20220330
IS  - 1432-2072 (Electronic)
IS  - 0033-3158 (Linking)
VI  - 223
IP  - 3
DP  - 2012 Oct
TI  - Blueberry supplementation induces spatial memory improvements and region-specific 
      regulation of hippocampal BDNF mRNA expression in young rats.
PG  - 319-30
LID - 10.1007/s00213-012-2719-8 [doi]
AB  - RATIONALE: Flavonoid-rich foods have been shown to be able to reverse age-related 
      cognitive deficits in memory and learning in both animals and humans. However, to 
      date, there have been only a limited number of studies investigating the effects 
      of flavonoid-rich foods on cognition in young/healthy animals. OBJECTIVES: The 
      aim of this study was to investigate the effects of a blueberry-rich diet in 
      young animals using a spatial working memory paradigm, the delayed non-match 
      task, using an eight-arm radial maze. Furthermore, the mechanisms underlying such 
      behavioural effects were investigated. RESULTS: We show that a 7-week 
      supplementation with a blueberry diet (2 % w/w) improves the spatial memory 
      performance of young rats (2 months old). Blueberry-fed animals also exhibited a 
      faster rate of learning compared to those on the control diet. These behavioural 
      outputs were accompanied by the activation of extracellular signal-related kinase 
      (ERK1/2), increases in total cAMP-response element-binding protein (CREB) and 
      elevated levels of pro- and mature brain-derived neurotrophic factor (BDNF) in 
      the hippocampus. Changes in hippocampal CREB correlated well with memory 
      performance. Further regional analysis of BDNF gene expression in the hippocampus 
      revealed a specific increase in BDNF mRNA in the dentate gyrus and CA1 areas of 
      hippocampi of blueberry-fed animals. CONCLUSIONS: The present study suggests that 
      consumption of flavonoid-rich blueberries has a positive impact on spatial 
      learning performance in young healthy animals, and these improvements are linked 
      to the activation of ERK-CREB-BDNF pathway in the hippocampus.
FAU - Rendeiro, Catarina
AU  - Rendeiro C
AD  - Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of 
      Reading, Reading, RG6 6AP, UK.
FAU - Vauzour, David
AU  - Vauzour D
FAU - Kean, Rebecca J
AU  - Kean RJ
FAU - Butler, Laurie T
AU  - Butler LT
FAU - Rattray, Marcus
AU  - Rattray M
FAU - Spencer, Jeremy P E
AU  - Spencer JP
FAU - Williams, Claire M
AU  - Williams CM
LA  - eng
GR  - BB/F008953/1/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120509
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Flavonoids)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Aging/drug effects
MH  - Animals
MH  - Blotting, Western
MH  - *Blueberry Plants/chemistry
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cognition Disorders/diet therapy
MH  - Flavonoids/administration & dosage/pharmacology
MH  - Fruit/chemistry
MH  - *Gene Expression Regulation/drug effects
MH  - Hippocampus/drug effects/*metabolism
MH  - Male
MH  - *Memory/drug effects
MH  - RNA, Messenger/*genetics
MH  - Rats
MH  - Rats, Inbred Strains
MH  - *Spatial Behavior/drug effects
EDAT- 2012/05/10 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/05/10 06:00
PHST- 2011/11/18 00:00 [received]
PHST- 2012/04/03 00:00 [accepted]
PHST- 2012/05/10 06:00 [entrez]
PHST- 2012/05/10 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 10.1007/s00213-012-2719-8 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2012 Oct;223(3):319-30. doi: 
      10.1007/s00213-012-2719-8. Epub 2012 May 9.