PMID- 22571725
OWN - NLM
STAT- MEDLINE
DCOM- 20121210
LR  - 20211021
IS  - 1944-0057 (Electronic)
IS  - 1944-0049 (Print)
IS  - 1944-0057 (Linking)
VI  - 29
IP  - 8
DP  - 2012 Aug
TI  - Comparability and repeatability of methods for estimating the dietary intake of 
      the heterocyclic amine contaminant 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine 
      (PhIP).
PG  - 1202-11
LID - 10.1080/19440049.2012.682657 [doi]
AB  - Inconsistent risk estimates for dietary heterocyclic amine (HCA) exposure and 
      cancers may be due to differences in exposure assessment methods and the 
      associated measurement error. We evaluated repeatability and comparability of 
      intake estimates of the HCA 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) 
      among two food frequency questionnaire (FFQ) collections, three diary 
      collections, and three measurements of urinary PhIP and its metabolites in 36 
      non-smokers in Baltimore, Maryland, during 2004-2005. Collections spanned  approximately 9 
      months. Method repeatability was characterised with intraclass correlation 
      coefficients (ICCs). Comparability among methods was assessed with Spearman 
      correlation coefficients. Within-subject variability in PhIP intake was 
      comparably high across all methods (ICCs of 0.20, 0.30, and 0.15 for FFQ, diary, 
      and creatinine-adjusted urinary PhIP, respectively). Mean diary-based PhIP intake 
      and mean urinary PhIP concentration were strongly correlated when restricting the 
      analysis to participants with at least one non-zero diary-based estimate of PhIP 
      intake (n = 15, r = 0.75, p = 0.001), but not in the full study population 
      (n = 36, r = 0.18, p = 0.28). Mean PhIP intake from the FFQ was not associated 
      with that either based on the diary or urinary PhIP separately, but was modestly 
      correlated with a metric that combined the diary- and biomarker-based approaches 
      (r = 0.30, p = 0.08). The high within-subject variability will result in 
      significantly attenuated associations if a single measure is used to estimate 
      exposure within an epidemiologic study. Improved HCA assessment tools, such as a 
      combination of methods or validated biomarkers that capture long term exposure, 
      are needed.
FAU - Deziel, Nicole C
AU  - Deziel NC
AD  - Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of 
      Public Health, 615 N. Wolfe St., Baltimore, MD, USA. dezielnc@mail.nih.gov
FAU - Buckley, Timothy J
AU  - Buckley TJ
FAU - Sinha, Rashmi
AU  - Sinha R
FAU - Abubaker, Salahaddhin
AU  - Abubaker S
FAU - Platz, Elizabeth A
AU  - Platz EA
FAU - Strickland, Paul T
AU  - Strickland PT
LA  - eng
GR  - T42 OH008428/OH/NIOSH CDC HHS/United States
GR  - Z99 CA999999/ImNIH/Intramural NIH HHS/United States
GR  - T42-OH-008428/OH/NIOSH CDC HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20120509
PL  - England
TA  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess
JT  - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & 
      risk assessment
JID - 101485040
RN  - 0 (Biomarkers)
RN  - 0 (Carcinogens)
RN  - 0 (Imidazoles)
RN  - 909C6UN66T (2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine)
SB  - IM
MH  - Biomarkers/urine
MH  - Carcinogens/*administration & dosage/analysis
MH  - Case-Control Studies
MH  - Diet/*adverse effects
MH  - Diet Records
MH  - Female
MH  - Follow-Up Studies
MH  - *Food Contamination
MH  - Humans
MH  - Imidazoles/*administration & dosage/urine
MH  - Male
MH  - Maryland
MH  - Meat/adverse effects/analysis
MH  - Reproducibility of Results
MH  - Risk Assessment/methods
MH  - Surveys and Questionnaires
PMC - PMC3412362
MID - NIHMS377332
COIS- Conflict of Interest Disclosure Statement: The authors declare that they have no 
      conflicts of interest.
EDAT- 2012/05/11 06:00
MHDA- 2012/12/12 06:00
PMCR- 2013/08/01
CRDT- 2012/05/11 06:00
PHST- 2012/05/11 06:00 [entrez]
PHST- 2012/05/11 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
PHST- 2013/08/01 00:00 [pmc-release]
AID - 10.1080/19440049.2012.682657 [doi]
PST - ppublish
SO  - Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2012 
      Aug;29(8):1202-11. doi: 10.1080/19440049.2012.682657. Epub 2012 May 9.