PMID- 22572536
OWN - NLM
STAT- MEDLINE
DCOM- 20120910
LR  - 20120704
IS  - 1421-9662 (Electronic)
IS  - 0001-5792 (Linking)
VI  - 128
IP  - 1
DP  - 2012
TI  - Correlations between HLA-A, HLA-B and HLA-DRB1 allele polymorphisms and childhood 
      susceptibility to acquired aplastic anemia.
PG  - 23-7
LID - 10.1159/000337094 [doi]
AB  - To investigate the correlations between polymorphisms of human leukocyte antigen 
      (HLA)-A, HLA-B and HLA-DRB1 alleles and childhood susceptibility to aplastic 
      anemia (AA), 80 children with AA were investigated. Among the 80 children, 74 had 
      severe AA (SAA). Blood samples were collected from 109 healthy children as the 
      controls. High-resolution genotyping of HLA-A, HLA-B and HLA-DRB1 alleles was 
      conducted using polymerase chain reaction amplification with sequence-specific 
      primers and polymerase chain reaction amplification with sequence-based typing. 
      The expression frequencies of HLA-B*48:01 and DRB1*09:01 were significantly 
      higher and the frequencies of HLA-B*51:01, DRB1*03:01 and DRB1*11:01 were 
      significantly lower in the AA group compared with those in the control group. In 
      addition, the frequencies of HLA-B*48:01 and DRB1*09:01 were significantly higher 
      and the frequencies of HLA-B*51:01, DRB1*03:01 and DRB1*11:01 were significantly 
      lower in the SAA group compared with those in the control group. HLA-B*48:01 and 
      DRB1*09:01 were correlated with childhood AA, and thus they may be susceptibility 
      genes for childhood SAA. HLA-B*51:01, DRB1*03:01 and DRB1*11:01 are expressed at 
      low levels in children with AA.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Chen, Chun
AU  - Chen C
AD  - Pediatrics of Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 
      PR China.
FAU - Lu, Suying
AU  - Lu S
FAU - Luo, Min
AU  - Luo M
FAU - Zhang, Bihong
AU  - Zhang B
FAU - Xiao, Lulu
AU  - Xiao L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120508
PL  - Switzerland
TA  - Acta Haematol
JT  - Acta haematologica
JID - 0141053
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B*52:01 antigen)
RN  - 0 (HLA-B52 Antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
RN  - 0 (HLA-DRB1*11:01 antigen)
SB  - IM
MH  - Adolescent
MH  - Alleles
MH  - Anemia, Aplastic/diagnosis/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-A Antigens/*genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-B52 Antigen/genetics
MH  - HLA-DRB1 Chains/*genetics
MH  - Humans
MH  - Infant
MH  - Male
MH  - *Polymorphism, Genetic
EDAT- 2012/05/11 06:00
MHDA- 2012/09/11 06:00
CRDT- 2012/05/11 06:00
PHST- 2011/09/13 00:00 [received]
PHST- 2012/02/07 00:00 [accepted]
PHST- 2012/05/11 06:00 [entrez]
PHST- 2012/05/11 06:00 [pubmed]
PHST- 2012/09/11 06:00 [medline]
AID - 000337094 [pii]
AID - 10.1159/000337094 [doi]
PST - ppublish
SO  - Acta Haematol. 2012;128(1):23-7. doi: 10.1159/000337094. Epub 2012 May 8.