PMID- 22572679
OWN - NLM
STAT- MEDLINE
DCOM- 20120914
LR  - 20151119
IS  - 1421-9875 (Electronic)
IS  - 0257-2753 (Linking)
VI  - 30
IP  - 1
DP  - 2012
TI  - Biomarkers in diverticular diseases of the colon.
PG  - 12-8
LID - 10.1159/000335695 [doi]
AB  - Recent data found that diverticular disease (DD) of the colon shows similarities 
      with inflammatory bowel diseases (IBD). In particular, the detection of 
      microscopic inflammation and the clinical response to mesalazine seem to confirm 
      the hypothesis that inflammation may be a key point for the appearance of 
      symptoms and development of complications. In light of this hypothesis, several 
      studies have recently focused their attention on the role of biomarkers in 
      predicting and monitoring the course of the disease. C-reactive protein (CRP), 
      white blood cell count, erythrocyte sedimentation rate, and fecal calprotectin 
      (FC) have therefore been investigated. As in IBD, CRP seems to be the most 
      effective marker of histological and clinical severity of the disease. In 
      particular, CRP below 50 mg/l suggests an acute uncomplicated diverticulitis 
      (AUD), whereas CRP higher than 200 mg/l is a strong indicator of DD complicated 
      by perforation. As in IBD, FC seems to be a noninvasive sensitive marker of DD 
      severity. In particular, FC may show slight increased valued already in 
      symptomatic uncomplicated DD (SUDD) (FC value >/=15 mug/ml seems to be predictive of 
      SUDD). As expected, FC shows higher values in AUD (FC value >/=60 mug/ml seems to be 
      predictive of AUD). Finally, FC seems to be useful also in monitoring the 
      therapeutic response in DD. In fact, FC values decreased significantly in 
      patients responding to therapy, whereas they persisted to increase in patients 
      who failed to obtain remission.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Tursi, Antonio
AU  - Tursi A
AD  - Servizio di Gastroenterologia Territoriale, ASL BAT, Andria, Italy. 
      antotursi@tiscali.it
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120503
PL  - Switzerland
TA  - Dig Dis
JT  - Digestive diseases (Basel, Switzerland)
JID - 8701186
RN  - 0 (Biomarkers)
SB  - IM
MH  - Biomarkers/*metabolism
MH  - Colon/*pathology
MH  - Diverticulitis, Colonic/*diagnosis
MH  - Feces
MH  - Humans
MH  - Inflammation/pathology
MH  - Inflammatory Bowel Diseases/diagnosis
EDAT- 2012/05/11 06:00
MHDA- 2012/09/15 06:00
CRDT- 2012/05/11 06:00
PHST- 2012/05/11 06:00 [entrez]
PHST- 2012/05/11 06:00 [pubmed]
PHST- 2012/09/15 06:00 [medline]
AID - 000335695 [pii]
AID - 10.1159/000335695 [doi]
PST - ppublish
SO  - Dig Dis. 2012;30(1):12-8. doi: 10.1159/000335695. Epub 2012 May 3.