PMID- 22573780
OWN - NLM
STAT- MEDLINE
DCOM- 20120725
LR  - 20230216
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 142
IP  - 6
DP  - 2012 Jun
TI  - The use of low-calorie sweeteners by children: implications for weight 
      management.
PG  - 1155S-62S
LID - 10.3945/jn.111.149609 [doi]
AB  - The rise in pediatric obesity since the 1970s has been well established in the 
      United States and is becoming a major concern worldwide. As a potential means to 
      help slow the obesity epidemic, low-calorie sweeteners (LCS) have gained 
      attention as dietary tools to assist in adherence to weight loss plans or 
      prevention of excess weight gain. Observational studies tend to show positive 
      correlations between LCS consumption and weight gain in children and adolescents. 
      Although the data are intriguing, these epidemiologic studies do not establish 
      that LCS cause weight gain, because there are likely many lifestyle and genetic 
      differences between children and families who choose to consume LCS and those who 
      do not. Short-term randomized controlled trials have shown LCS use to be BMI 
      neutral or to have modest weight-reducing effects in overweight and obese 
      adolescents. The long-term effects of LCS in children and adolescents are 
      unknown. Some compelling research is currently underway and may provide needed 
      insight into the potential role of LCS in weight management. The paucity of data 
      regarding the effects of LCS use in children and adolescents creates challenges 
      in decision-making for health care providers and parents.
FAU - Foreyt, John
AU  - Foreyt J
AD  - Baylor College of Medicine, Houston, TX, USA. jforeyt@bcm.edu
FAU - Kleinman, Ronald
AU  - Kleinman R
FAU - Brown, Rebecca J
AU  - Brown RJ
FAU - Lindstrom, Rachel
AU  - Lindstrom R
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
DEP - 20120509
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Sweetening Agents)
SB  - IM
MH  - Adolescent
MH  - Adolescent Nutritional Physiological Phenomena
MH  - Child
MH  - Child Nutritional Physiological Phenomena
MH  - Child, Preschool
MH  - *Energy Intake
MH  - Humans
MH  - Infant
MH  - *Obesity/epidemiology/prevention & control
MH  - Sweetening Agents/*administration & dosage
MH  - United States/epidemiology
MH  - *Weight Loss
PMC - PMC3738224
COIS- Author disclosures: R. Kleinman has served on an advisory committee for 
      Ajinomoto. J. Foreyt has received consulting fees, honoraria, and unrestricted 
      grants from food, beverage, and pharmaceutical companies and from government and 
      nonprofit sources. R. J. Brown's research was supported in part by the Intramural 
      Research Program of the National Institute of Diabetes, Digestive, and Kidney 
      Diseases. R. Lindstrom, no conflicts of interest.
EDAT- 2012/05/11 06:00
MHDA- 2012/07/26 06:00
PMCR- 2012/05/09
CRDT- 2012/05/11 06:00
PHST- 2012/05/11 06:00 [entrez]
PHST- 2012/05/11 06:00 [pubmed]
PHST- 2012/07/26 06:00 [medline]
PHST- 2012/05/09 00:00 [pmc-release]
AID - S0022-3166(22)02771-7 [pii]
AID - 149609 [pii]
AID - 10.3945/jn.111.149609 [doi]
PST - ppublish
SO  - J Nutr. 2012 Jun;142(6):1155S-62S. doi: 10.3945/jn.111.149609. Epub 2012 May 9.