PMID- 22573781
OWN - NLM
STAT- MEDLINE
DCOM- 20120725
LR  - 20230216
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Linking)
VI  - 142
IP  - 6
DP  - 2012 Jun
TI  - The use of low-calorie sweeteners by adults: impact on weight management.
PG  - 1163S-9S
LID - 10.3945/jn.111.149617 [doi]
AB  - The application of low-calorie sweeteners (LCS) in foods and beverages has 
      increased over the past 35 y. At the same time, many characteristics of the 
      American diet have changed, including variations in fat and carbohydrate content 
      and composition, increased nutrient additions, and new dietary patterns due to 
      changing lifestyles and attitudes toward food and the changing cost of food. 
      During this same time period, the prevalence of overweight and obesity has 
      increased from ~30 to 70% of adults in the United States. Clearly, these trends 
      lead to a variety of hypotheses and efforts to explain the role of LCS in this 
      association. The aim of this review is to gain clarity on the role of LCS in 
      weight management and their impact on diet quality. In addition, because the 
      majority of studies aimed at identifying associations between LCS and these 
      outcomes are based on observational data, the pitfalls in designing and 
      evaluating data from observational studies are also discussed. We conclude that 
      there is no evidence that LCS can be claimed to be a cause of higher body weights 
      in adults. Similarly, evidence supporting a role for LCS in weight management is 
      lacking. Due to the confounders in most observational studies, randomized 
      controlled trials are needed to advance understanding.
FAU - Anderson, G Harvey
AU  - Anderson GH
AD  - University of Toronto, Department of Nutritional Sciences, Toronto, Ontario, 
      Canada. harvey.anderson@utoronto.ca
FAU - Foreyt, John
AU  - Foreyt J
FAU - Sigman-Grant, Madeleine
AU  - Sigman-Grant M
FAU - Allison, David B
AU  - Allison DB
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120509
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Sweetening Agents)
SB  - IM
MH  - Adult
MH  - Diet/*standards
MH  - Energy Intake/*drug effects
MH  - Humans
MH  - Nutritive Value
MH  - Obesity/*prevention & control
MH  - Sweetening Agents/*pharmacology
MH  - United States
EDAT- 2012/05/11 06:00
MHDA- 2012/07/26 06:00
CRDT- 2012/05/11 06:00
PHST- 2012/05/11 06:00 [entrez]
PHST- 2012/05/11 06:00 [pubmed]
PHST- 2012/07/26 06:00 [medline]
AID - S0022-3166(22)02772-9 [pii]
AID - 10.3945/jn.111.149617 [doi]
PST - ppublish
SO  - J Nutr. 2012 Jun;142(6):1163S-9S. doi: 10.3945/jn.111.149617. Epub 2012 May 9.