PMID- 22573784
OWN - NLM
STAT- MEDLINE
DCOM- 20120725
LR  - 20230216
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 142
IP  - 6
DP  - 2012 Jun
TI  - Mechanisms for sweetness.
PG  - 1134S-41S
LID - 10.3945/jn.111.149567 [doi]
AB  - A remarkable amount of information has emerged in the past decade regarding sweet 
      taste physiology. This article reviews these data, with a particular focus on the 
      elucidation of the sweet taste receptor, its location and actions in taste 
      transduction in the mouth, its nontaste functions in the gastrointestinal tract 
      (e.g., in enteroendocrine cells), and the brain circuitry involved in the sensory 
      processing of sweet taste. Complications in the use of rodents to model human 
      sweet taste perception and responses are also considered. In addition, 
      information relating to low-calorie sweeteners (LCS) is discussed in the context 
      of these issues. Particular consideration is given to the known effects of LCS on 
      enteroendocrine cell function.
FAU - Fernstrom, John D
AU  - Fernstrom JD
AD  - University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 
      fernstromjd@upmc.edu
FAU - Munger, Steven D
AU  - Munger SD
FAU - Sclafani, Anthony
AU  - Sclafani A
FAU - de Araujo, Ivan E
AU  - de Araujo IE
FAU - Roberts, Ashley
AU  - Roberts A
FAU - Molinary, Samuel
AU  - Molinary S
LA  - eng
GR  - DC010110/DC/NIDCD NIH HHS/United States
GR  - DK 031135/DK/NIDDK NIH HHS/United States
GR  - R01 DC010110/DC/NIDCD NIH HHS/United States
GR  - R01 DK031135/DK/NIDDK NIH HHS/United States
GR  - Z01 DK031135/Intramural NIH HHS/United States
GR  - DC009997/DC/NIDCD NIH HHS/United States
GR  - R01 DC005633/DC/NIDCD NIH HHS/United States
GR  - R37 DK031135/DK/NIDDK NIH HHS/United States
GR  - DC005633/DC/NIDCD NIH HHS/United States
GR  - R01 DC009997/DC/NIDCD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20120509
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Sweetening Agents)
SB  - IM
MH  - Animals
MH  - Humans
MH  - Models, Animal
MH  - Sweetening Agents/chemistry/*pharmacology
MH  - Taste/*physiology
MH  - Taste Buds/physiology
MH  - Taste Perception/*physiology
PMC - PMC3738222
COIS- Author disclosures: J. D. Fernstrom is a scientific consultant to the Ajinomoto 
      Company. Research in S. D. Munger's laboratory is funded by the NIH/National 
      Institute on Deafness and Other Communication Disorders (DC005633, DC010110) and 
      by Tate and Lyle Americas, LLC. S. D. Munger has previously consulted with McNeil 
      Nutritionals LLC on the biology of sweet taste. A. Sclafani's laboratory is 
      funded by the NIH/National Institute of Diabetes and Digestive and Kidney 
      Diseases Digestive (DK 031135) and the Ajinomoto Amino Acid Research Program. S. 
      V. Molinary is a scientific consultant to the Tate and Lyle Company. Research in 
      I. E. de Araujo's laboratory is funded by the NIH/National Institute on Deafness 
      and Other Communication Disorders (DC009997). I. de Araujo and A. Roberts, no 
      conflicts of interest.
EDAT- 2012/05/11 06:00
MHDA- 2012/07/26 06:00
PMCR- 2012/05/09
CRDT- 2012/05/11 06:00
PHST- 2012/05/11 06:00 [entrez]
PHST- 2012/05/11 06:00 [pubmed]
PHST- 2012/07/26 06:00 [medline]
PHST- 2012/05/09 00:00 [pmc-release]
AID - S0022-3166(22)02768-7 [pii]
AID - 149567 [pii]
AID - 10.3945/jn.111.149567 [doi]
PST - ppublish
SO  - J Nutr. 2012 Jun;142(6):1134S-41S. doi: 10.3945/jn.111.149567. Epub 2012 May 9.