PMID- 22574564
OWN - NLM
STAT- MEDLINE
DCOM- 20120717
LR  - 20220410
IS  - 1000-0607 (Print)
IS  - 1000-0607 (Linking)
VI  - 37
IP  - 1
DP  - 2012 Feb
TI  - [Effect of acupuncture on expression of brain-derived neurotrophic factor gene 
      and protein in frontal cortex and hippocampus of depression rats].
PG  - 20-4
AB  - OBJECTIVE: To observe the influence of acupuncture of "Baihui" (GV 20) to 
      "Yintang" (EX-HN 3) and unilateral "Neiguan" (PC 6) on the expression of 
      brain-derived neurotrophic factor (BDNF) gene and protein in the prefrontal 
      cortex and hippocampus in chronic stress-induced depression rats. METHODS: 
      Sprague-Dawley rats were randomly divided into four groups (6 rats/group): 
      control, control + acupuncture, model, and model + acupuncture. Depression model 
      was established by giving the rats with repeated abstinence of food and water, 
      illumination at night, forced cold water-swimming, vibration, tail-clamping, 
      constraint and raising alone for 28 days. Acupuncture was applied to "Baihui" (GV 
      20) to "Yintang" (EX-HN 3) and unilateral "Neiguan"(PC 6) once every other day 
      for 28 days. The expression levels of BDNF mRNA and protein of the frontal cortex 
      and hippocampus tissues were detected by real-time fluorescence quantitative PCR 
      and Western blot methods, separately. RESULTS: Compared with the control group, 
      the expression levels of BDNF mRNA and protein in the prefrontal cortex and 
      hippocampus were significantly decreased in the model group (P < 0.01, P < 0.05). 
      Whereas compared with the model group, BDNF mRNA and protein expression levels in 
      the prefrontal cortex and hippocampus were significantly upregulated in the model 
      + acupuncture group (P < 0.05, P < 0.01). No significant differences were found 
      between the control and control + acupuncture groups in the expression levels of 
      cortical and hippocampal BDNF mRNA and protein (P > 0.05). CONCLUSION: 
      Acupuncture can effectively reverse chronic stress-induced down-regulation of 
      BDNF mRNA and protein expression in the frontal cortex and hippocampus in 
      depression rats, which may contribute to its effect in anti-depression by 
      protecting the regeneration of neurons.
FAU - Liang, Jia
AU  - Liang J
AD  - School of Acu-moxibustion and Tuina, Beijing University of Chinese Medicine, 
      Beijing 100029, China.
FAU - Lu, Jun
AU  - Lu J
FAU - Cui, Shan-Fu
AU  - Cui SF
FAU - Wang, Jun-Ren
AU  - Wang JR
FAU - Tu, Ya
AU  - Tu Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhen Ci Yan Jiu
JT  - Zhen ci yan jiu = Acupuncture research
JID - 8507710
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - *Acupuncture Therapy
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics/*metabolism
MH  - Cerebral Cortex/*metabolism
MH  - Depression/*genetics/metabolism/*therapy
MH  - Gene Expression Regulation
MH  - Hippocampus/*metabolism
MH  - Humans
MH  - Male
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2012/05/12 06:00
MHDA- 2012/07/18 06:00
CRDT- 2012/05/12 06:00
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2012/07/18 06:00 [medline]
PST - ppublish
SO  - Zhen Ci Yan Jiu. 2012 Feb;37(1):20-4.