PMID- 22574690
OWN - NLM
STAT- MEDLINE
DCOM- 20130530
LR  - 20211021
IS  - 1601-183X (Electronic)
IS  - 1601-1848 (Print)
IS  - 1601-183X (Linking)
VI  - 11
IP  - 6
DP  - 2012 Aug
TI  - Long-lasting regulation of hippocampal Bdnf gene transcription after contextual 
      fear conditioning.
PG  - 651-9
LID - 10.1111/j.1601-183X.2012.00805.x [doi]
AB  - Long-term memory formation requires de novo protein synthesis and gene 
      transcription. During contextual long-term memory formation brain-derived 
      neurotrophic factor (BDNF) gene expression changes in conjunction with 
      alterations of DNA methylation in the Bdnf gene. However, little is known about 
      the molecular mechanisms underlying the maintenance and persistence of contextual 
      long-term memory. Here, we examined the transcription of specific Bdnf exons in 
      the hippocampus for long periods after contextual fear conditioning. We found 
      changes in transcription lasting for at least 24 h after contextual fear 
      conditioning, with some sex-specific effects. In addition, hypomethylation at a 
      CpG site in CpG island 2 located at the end of Bdnf exon III sequence was 
      detected at 0.5 h and maintained for up to 24 h after contextual fear 
      conditioning. The identification of these long-lasting changes in transcription 
      and DNA methylation at the Bdnf gene suggests that BDNF might have a role for 
      storage of contextual long-term memory in the hippocampus.
CI  - (c) 2012 The Authors. Genes, Brain and Behavior (c) 2012 Blackwell Publishing Ltd and 
      International Behavioural and Neural Genetics Society.
FAU - Mizuno, K
AU  - Mizuno K
AD  - King's College London, Centre for the Cellular Basis of Behaviour, Institute of 
      Psychiatry, London, UK. keiko.mizuno@kcl.ac.uk
FAU - Dempster, E
AU  - Dempster E
FAU - Mill, J
AU  - Mill J
FAU - Giese, K P
AU  - Giese KP
LA  - eng
GR  - R01 MH087463/MH/NIMH NIH HHS/United States
GR  - R01 MH-097463-01A1/MH/NIMH NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20120530
PL  - England
TA  - Genes Brain Behav
JT  - Genes, brain, and behavior
JID - 101129617
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Conditioning, Psychological/physiology
MH  - DNA Methylation/genetics
MH  - Fear/*physiology
MH  - Female
MH  - Hippocampus/*physiology
MH  - Male
MH  - Memory, Long-Term/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Sex Characteristics
MH  - Transcription, Genetic/*physiology
PMC - PMC3982390
MID - NIHMS465296
EDAT- 2012/05/12 06:00
MHDA- 2013/06/01 06:00
PMCR- 2014/04/10
CRDT- 2012/05/12 06:00
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2013/06/01 06:00 [medline]
PHST- 2014/04/10 00:00 [pmc-release]
AID - 10.1111/j.1601-183X.2012.00805.x [doi]
PST - ppublish
SO  - Genes Brain Behav. 2012 Aug;11(6):651-9. doi: 10.1111/j.1601-183X.2012.00805.x. 
      Epub 2012 May 30.