PMID- 22576416 OWN - NLM STAT- MEDLINE DCOM- 20130709 LR - 20211021 IS - 1439-6327 (Electronic) IS - 1439-6319 (Linking) VI - 113 IP - 1 DP - 2013 Jan TI - Time-course response in serum markers of bone turnover to a single-bout of electrical stimulation in patients with recent spinal cord injury. PG - 89-97 LID - 10.1007/s00421-012-2416-7 [doi] AB - The objective of the present repeat-measures study was to determine whether plasma serum levels of testosterone, cortisol, osteocalcin or type I collagen C-telopeptide (CT) are acutely affected following an electro-myostimulation (EMS) bout, and their relation to bone mineral density and muscle mass. Ten men with recent (8 weeks) thoracic spinal cord injury (SCI) (ASIA A) and 10 age-matched able-bodied (AB) men performed one EMS bout on the quadriceps femoris muscle. Blood samples were drawn at basal condition, immediately after EMS, and 15 min, 30 min, 24 h and 48 h post-EMS. Muscle cross-sectional area was measured by magnetic resonance imaging. Bone mineral density (BMD) was determined by dual-energy X-ray absorptiometry. In the SCI group, a significant decrease in testosterone, cortisol and CT together with a significant increase in testosterone/cortisol ratio and osteocalcin/CT ratio was observed after EMS. For the AB subjects, only testosterone and CT decreased significantly following EMS. Muscle size was only related to testosterone/cortisol ratio in the SCI sample (R = 0.659, p < 0.05), whereas BMD did not show any relation to any biomarker. Acute EMS in recent spinal cord injured men seems to induce positive effects on bone turnover biomarkers, and anabolic and catabolic hormones. FAU - Arija-Blazquez, Alfredo AU - Arija-Blazquez A AD - Faculty of Sport Sciences, UCLM, Av. Carlos III s/n, 45071 Toledo, Spain. alfredoarija@gmail.com FAU - Ceruelo-Abajo, Silvia AU - Ceruelo-Abajo S FAU - Diaz-Merino, Maria S AU - Diaz-Merino MS FAU - Godino-Duran, Juan Antonio AU - Godino-Duran JA FAU - Martinez-Dhier, Luis AU - Martinez-Dhier L FAU - Florensa-Vila, Jose AU - Florensa-Vila J LA - eng PT - Controlled Clinical Trial PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20120511 PL - Germany TA - Eur J Appl Physiol JT - European journal of applied physiology JID - 100954790 RN - 0 (Biomarkers) RN - 0 (Hormones) SB - IM MH - Adult MH - Biomarkers/blood MH - Bone Density MH - Bone and Bones/*physiopathology MH - Electric Stimulation Therapy/*methods MH - Hormones/*blood MH - Humans MH - Male MH - Muscular Atrophy/etiology/*physiopathology/*rehabilitation MH - Organ Size MH - Spinal Cord Injuries/*physiopathology/*rehabilitation MH - Treatment Outcome EDAT- 2012/05/12 06:00 MHDA- 2013/07/10 06:00 CRDT- 2012/05/12 06:00 PHST- 2012/01/20 00:00 [received] PHST- 2012/04/30 00:00 [accepted] PHST- 2012/05/12 06:00 [entrez] PHST- 2012/05/12 06:00 [pubmed] PHST- 2013/07/10 06:00 [medline] AID - 10.1007/s00421-012-2416-7 [doi] PST - ppublish SO - Eur J Appl Physiol. 2013 Jan;113(1):89-97. doi: 10.1007/s00421-012-2416-7. Epub 2012 May 11.