PMID- 22576830
OWN - NLM
STAT- MEDLINE
DCOM- 20120822
LR  - 20221207
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 11
IP  - 1
DP  - 2012 Mar 22
TI  - BDNF and DARPP-32 genes are not risk factors for schizophrenia in the Malay 
      population.
PG  - 725-30
LID - 10.4238/2012.March.22.2 [doi]
AB  - A number of studies have pointed to the association of BDNF (brain-derived 
      neurotrophic factor) and DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 
      32 kDa) with schizophrenia. The purpose of this study was to determine whether 
      these two genes are involved in the pathogenesis of schizophrenia in the Malay 
      population. Two single nucleotide polymorphisms Val66Met of BDNF, -2036C>G and 
      g.1238delG of DARPP-32 were genotyped in the Malay population in 200 patients 
      with schizophrenia and 256 healthy controls. Analysis of allele and genotype 
      frequencies in these two groups revealed no significant association of BDNF or 
      DARPP-32 polymorphisms with schizophrenia in Malays. This is the first such 
      association study in the Malay population.
FAU - Loh, H C
AU  - Loh HC
AD  - Department of Chemical Engineering, Faculty of Engineering and Science, 
      Universiti Tunku Abdul Rahman, Setapak, Kuala Lumpur, Malaysia. hcloh@utar.edu.my
FAU - Tang, P Y
AU  - Tang PY
FAU - Tee, S F
AU  - Tee SF
FAU - Chow, T J
AU  - Chow TJ
FAU - Cheah, Y C
AU  - Cheah YC
FAU - Singh, S S J
AU  - Singh SS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120322
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dopamine and cAMP-Regulated Phosphoprotein 32)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Asian People/genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Dopamine and cAMP-Regulated Phosphoprotein 32/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Malaysia
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Risk Factors
MH  - Schizophrenia/*genetics
EDAT- 2012/05/12 06:00
MHDA- 2012/08/23 06:00
CRDT- 2012/05/12 06:00
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2012/08/23 06:00 [medline]
AID - gmr1472 [pii]
AID - 10.4238/2012.March.22.2 [doi]
PST - epublish
SO  - Genet Mol Res. 2012 Mar 22;11(1):725-30. doi: 10.4238/2012.March.22.2.