PMID- 22577076
OWN - NLM
STAT- MEDLINE
DCOM- 20120814
LR  - 20220330
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 53
IP  - 8
DP  - 2012 Jul 1
TI  - Detection of localized retinal nerve fiber layer defects with posterior pole 
      asymmetry analysis of spectral domain optical coherence tomography.
PG  - 4347-53
LID - 10.1167/iovs.12-9673 [doi]
AB  - PURPOSE: To investigate the diagnostic ability of posterior pole asymmetry 
      analysis (PPAA) with spectral domain optical coherence tomography (SD-OCT) for 
      detecting localized retinal nerve fiber layer defects (RNFLD). METHODS: 
      Eighty-four open-angle glaucoma subjects (84 eyes) with localized, wedge-shape 
      RNFLDs by red-free RNFL photography and 122 eyes of healthy subjects were 
      enrolled. The subjects were examined by SD-OCT to obtain circumpapillary RNFL 
      (cpRNFL) thickness as well as PPAA. The PPAA provides a corresponding cell to 
      cell comparison between hemispheres within the central 20 degrees  and presents the 
      difference using gray scale. Area under the receiver operating characteristic 
      curve (AUROC) was calculated. The sensitivity and specificity of PPAA to detect 
      glaucoma with the localized defects were also examined using various criteria; 
      two consecutive black cells (criterion A), three consecutive black cells 
      (criterion B), and four consecutive black cells (criterion C). RESULTS: An AUROC 
      of PPAA based on the number of black cells was 0.958 +/- 0.013. The sensitivity and 
      specificity of PPAA were 95.2% and 81.1% for criterion A, 83.3% and 92.6% for 
      criterion B, and 69.0% and 98.4% for criterion C, respectively. The sensitivity 
      and specificity of the cpRNFL thickness were 85.7% and 95.1%, respectively. 
      CONCLUSIONS: SD-OCT PPAA detects localized RNFLDs with high sensitivity and 
      specificity, which are comparable to the cpRNFL thickness profile of OCT. These 
      findings suggest that the PPAA can be complementary to other tests for diagnosing 
      glaucoma in patients with localized RNFLDs.
FAU - Seo, Je Hyun
AU  - Seo JH
AD  - Department of Ophthalmology, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Kim, Tae-Woo
AU  - Kim TW
FAU - Weinreb, Robert N
AU  - Weinreb RN
FAU - Park, Ki Ho
AU  - Park KH
FAU - Kim, Seok Hwan
AU  - Kim SH
FAU - Kim, Dong Myung
AU  - Kim DM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120701
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Area Under Curve
MH  - Female
MH  - Glaucoma, Open-Angle/*diagnosis
MH  - Humans
MH  - Intraocular Pressure
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Optic Disk/*pathology
MH  - Optic Nerve Diseases/*diagnosis
MH  - ROC Curve
MH  - Retinal Ganglion Cells/*pathology
MH  - Sensitivity and Specificity
MH  - *Tomography, Optical Coherence
MH  - Tonometry, Ocular
MH  - Visual Field Tests
MH  - Visual Fields
EDAT- 2012/05/12 06:00
MHDA- 2012/08/15 06:00
CRDT- 2012/05/12 06:00
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2012/08/15 06:00 [medline]
AID - iovs.12-9673 [pii]
AID - 10.1167/iovs.12-9673 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2012 Jul 1;53(8):4347-53. doi: 10.1167/iovs.12-9673.