PMID- 22577415
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2251-6638 (Electronic)
IS  - 1735-3955 (Print)
IS  - 1735-3955 (Linking)
VI  - 6
IP  - 2
DP  - 2010 Summer
TI  - Relationship Between Carotid Intima-Media Thickness with some Inflammatory 
      Biomarkers, Ghrelin and Adiponectin in Iranians with and without Metabolic 
      Syndrome in Isfahan Cohort Study.
PG  - 56-61
AB  - BACKGROUND: Recent studies have confirmed inflammatory factors and metabolic 
      syndrome (MetS) as important cardiovascular disease (CVD) risk factors. Recently 
      measurement of carotid intima-media thickness (IMT) has been used for evaluation 
      of early atherosclerosis. This study was designed to assess the correlation 
      between IMT with some inflammatory biomarkers, ghrelin and adiponectin in people 
      with and without MetS in a cohort sample in Isfahan province. METHODS: Among 
      participants of Isfahan Cohort Study (ICS) by random sampling, 88 participants 
      were selected and divided into case (with MetS) and control (without MetS) 
      groups. A questionnaire including demographic data and CVD risk factors was 
      completed for all of the participants. Physical examination and blood pressure, 
      height, weight and waist circumference measurements were done for all subjects. 
      Vascular echocardiography was done for evaluation of IMT of each carotid artery 
      of both sides. Interlukin-6 (IL-6), interlukin-10 (IL-10), highly sensitive 
      C-reactive protein (hs-CRP), ghrelin and adiponectin levels were measured using 
      ELIZA method. Data were entered in SPSS(15) software and analyzed by t-test, chi 
      square, Pearson correlation and linear regression analyze. RESULTS: The mean 
      waist circumference, BMI, systolic blood pressure, diastolic blood pressure, 
      hs-CRP and IMT of left carotid artery were significantly higher in participants 
      with Mets. There was significant correlation between left carotid IMT and IL-6 
      level in all patients (P = 0.03). After adjustment for age and sex, significant 
      relationship in groups with MetS was only reported between the left IMT and IL-6 
      (P = 0.02). There was no relation between IMT and other inflammatory markers in 
      subjects with and without MetS. CONCLUSION: Significant correlation between IL-6 
      and IMT was reported in patients with MetS. While no significant correlation 
      between IL-10, adiponectin and ghrelin with IMT was observed in metabolic 
      syndrome group.
FAU - Hajmohammadi, Taiebeh
AU  - Hajmohammadi T
AD  - Resident of Cardiology, Isfahan University of Medical Sciences.
FAU - Sadeghi, Masoumeh
AU  - Sadeghi M
FAU - Dashti, Masoumeh
AU  - Dashti M
FAU - Hashemi, Mohammad
AU  - Hashemi M
FAU - Saadatnia, Mohammad
AU  - Saadatnia M
FAU - Soghrati, Mojgan
AU  - Soghrati M
FAU - Talaei, Mohammad
AU  - Talaei M
FAU - Sarrafzadegan, Nizal
AU  - Sarrafzadegan N
LA  - eng
PT  - Journal Article
PL  - Iran
TA  - ARYA Atheroscler
JT  - ARYA atherosclerosis
JID - 101487337
PMC - PMC3347812
OTO - NOTNLM
OT  - Adiponectin IL-6
OT  - Carotid artery
OT  - Ghrelin
OT  - IL-10
OT  - Intima-media thickness (IMT)
OT  - hs-CRP
EDAT- 2010/07/01 00:00
MHDA- 2010/07/01 00:01
PMCR- 2010/06/01
CRDT- 2012/05/12 06:00
PHST- 2009/12/15 00:00 [received]
PHST- 2010/06/17 00:00 [accepted]
PHST- 2012/05/12 06:00 [entrez]
PHST- 2010/07/01 00:00 [pubmed]
PHST- 2010/07/01 00:01 [medline]
PHST- 2010/06/01 00:00 [pmc-release]
AID - ARYA-06-056 [pii]
PST - ppublish
SO  - ARYA Atheroscler. 2010 Summer;6(2):56-61.