PMID- 2257742
OWN - NLM
STAT- MEDLINE
DCOM- 19910131
LR  - 20190824
IS  - 0010-7824 (Print)
IS  - 0010-7824 (Linking)
VI  - 42
IP  - 4
DP  - 1990 Oct
TI  - A pharmacodynamic and pharmacokinetic study of the Chinese No. 1 pill.
PG  - 439-53
AB  - A pharmacodynamic and pharmacokinetic study of the Chinese No. 1 pill, a combined 
      oral contraceptive containing 35 micrograms ethynyloestradiol (EE) and 600 
      micrograms norethisterone (NET), was performed in 29 women over a period of six 
      months. Blood samples for analysis were taken during a pretreatment cycle, the 
      first and 6th treatment cycles and post-treatment. Minor changes in carbohydrate 
      metabolism occurred and these were particularly noticeable when the incremental 
      areas under the serum concentration-time curves for both glucose and insulin in 
      response to a glucose tolerance test were calculated. No changes occurred in the 
      serum glycosylated haemoglobin levels. The serum concentrations of all the lipids 
      measured (total cholesterol, triglycerides, LDL-C, HDL-C and apolipoproteins AI, 
      AII and B) were significantly increased on treatment as were levels of Factor X, 
      SHBG and caeruloplasmin whereas antithrombin III decreased. In 38 of the 40 
      treatment cycles, ovulation was suppressed. In one cycle serum oestradiol and 
      progesterone levels showed a typical ovulatory pattern and in another there was 
      evidence of follicular activity without ovulation. Serum EE concentrations showed 
      a similar pattern in both treatment cycles showing that co-administration of NET 
      did not affect EE metabolism. Serum NET levels were higher in the 6th than in the 
      first treatment cycles. On comparing pharmacodynamic and pharmacokinetic 
      parameters, the only statistically significant correlations were between the 
      percentage change in triglycerides and SHBG and serum NET, but not EE 
      concentrations, and between apolipoproteins AI and serum EE.
FAU - Chen, J K
AU  - Chen JK
AD  - Institute of Planned Parenthood Research, Shanghai, China.
FAU - Song, S
AU  - Song S
FAU - Yang, P J
AU  - Yang PJ
FAU - He, M L
AU  - He ML
FAU - Fan, S B
AU  - Fan SB
FAU - Li, L M
AU  - Li LM
FAU - Gui, Y L
AU  - Gui YL
FAU - Fotherby, K
AU  - Fotherby K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Contraception
JT  - Contraception
JID - 0234361
RN  - 0 (Apolipoproteins)
RN  - 0 (Contraceptives, Oral, Combined)
RN  - 0 (Insulin)
RN  - 0 (Sex Hormone-Binding Globulin)
RN  - 423D2T571U (Ethinyl Estradiol)
RN  - 4G7DS2Q64Y (Progesterone)
RN  - 4TI98Z838E (Estradiol)
RN  - 9000-94-6 (Antithrombin III)
RN  - 9001-29-0 (Factor X)
RN  - 97C5T2UQ7J (Cholesterol)
RN  - EC 1.16.3.1 (Ceruloplasmin)
RN  - IY9XDZ35W2 (Glucose)
RN  - T18F433X4S (Norethindrone)
SB  - IM
MH  - Adult
MH  - Antithrombin III/chemistry
MH  - Apolipoproteins/blood
MH  - Ceruloplasmin/chemistry
MH  - Cholesterol/blood
MH  - Contraceptives, Oral, Combined/*pharmacokinetics
MH  - Estradiol/blood
MH  - Ethinyl Estradiol/*pharmacokinetics
MH  - Factor X/chemistry
MH  - Female
MH  - Glucose/metabolism
MH  - Humans
MH  - Insulin/blood
MH  - Norethindrone/*pharmacokinetics
MH  - Progesterone/blood
MH  - Sex Hormone-Binding Globulin/chemistry
OID - PIP: 063903
OID - POP: 00198646
OTO - PIP
OT  - Asia
OT  - Biology
OT  - *Carbohydrate Metabolic Effects
OT  - China
OT  - Contraception
OT  - Contraceptive Methods--pharmacodynamics
OT  - Contraceptive Usage
OT  - Developing Countries
OT  - Eastern Asia
OT  - Endocrine System
OT  - *Estradiol--analysis
OT  - Estrogens
OT  - Examinations And Diagnoses
OT  - Family Planning
OT  - *Glucose Metabolism Effects
OT  - *Hormones--analysis
OT  - *Laboratory Examinations And Diagnoses
OT  - Metabolic Effects
OT  - *Method Acceptability
OT  - *Oral Contraceptives--pharmacodynamics
OT  - Physiology
OT  - Progestational Hormones
OT  - *Progesterone--analysis
OT  - *Steroid Metabolic Effects
GN  - PIP: TJ: CONTRACEPTION.
EDAT- 1990/10/01 00:00
MHDA- 1990/10/01 00:01
CRDT- 1990/10/01 00:00
PHST- 1990/10/01 00:00 [pubmed]
PHST- 1990/10/01 00:01 [medline]
PHST- 1990/10/01 00:00 [entrez]
AID - 0010-7824(90)90051-V [pii]
AID - 10.1016/0010-7824(90)90051-v [doi]
PST - ppublish
SO  - Contraception. 1990 Oct;42(4):439-53. doi: 10.1016/0010-7824(90)90051-v.