PMID- 22577522
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20120823
LR  - 20231105
IS  - 2090-0430 (Electronic)
IS  - 2090-0422 (Print)
IS  - 2090-0430 (Linking)
VI  - 2012
DP  - 2012
TI  - Shared HLA Class II in Six Autoimmune Diseases in Latin America: A Meta-Analysis.
PG  - 569728
LID - 10.1155/2012/569728 [doi]
LID - 569728
AB  - The prevalence and genetic susceptibility of autoimmune diseases (ADs) may vary 
      depending on latitudinal gradient and ethnicity. The aims of this study were to 
      identify common human leukocyte antigen (HLA) class II alleles that contribute to 
      susceptibility to six ADs in Latin Americans through a meta-analysis and to 
      review additional clinical, immunological, and genetic characteristics of those 
      ADs sharing HLA alleles. DRB1( *)03:01 (OR: 4.04; 95%CI: 1.41-11.53) was found to 
      be a risk factor for systemic lupus erythematosus (SLE), Sjogren's syndrome (SS), 
      and type 1 diabetes mellitus (T1D). DRB1( *)04:05 (OR: 4.64; 95%CI: 2.14-10.05) 
      influences autoimmune hepatitis (AIH), rheumatoid arthritis (RA), and T1D; 
      DRB1( *)04:01 (OR: 3.86; 95%CI: 2.32-6.42) is a susceptibility factor for RA and 
      T1D. Opposite associations were found between multiple sclerosis (MS) and T1D. 
      DQB1( *)06:02 and DRB1( *)15 alleles were risk factors for MS but protective 
      factors for T1D. Likewise, DQB1( *)06:03 allele was a risk factor for AIH but a 
      protective one for T1D. Several common autoantibodies and clinical associations 
      as well as additional shared genes have been reported in these ADs, which are 
      reviewed herein. These results indicate that in Latin Americans ADs share major 
      loci and immune characteristics.
FAU - Cruz-Tapias, Paola
AU  - Cruz-Tapias P
AD  - Center for Autoimmune Diseases Research (CREA), School of Medicine and Health 
      Sciences, Universidad del Rosario, Carrera 24 No. 63C-69, Bogota, Colombia.
FAU - Perez-Fernandez, Oscar M
AU  - Perez-Fernandez OM
FAU - Rojas-Villarraga, Adriana
AU  - Rojas-Villarraga A
FAU - Rodriguez-Rodriguez, Alberto
AU  - Rodriguez-Rodriguez A
FAU - Arango, Maria-Teresa
AU  - Arango MT
FAU - Anaya, Juan-Manuel
AU  - Anaya JM
LA  - eng
PT  - Journal Article
DEP - 20120419
PL  - United States
TA  - Autoimmune Dis
JT  - Autoimmune diseases
JID - 101546750
PMC - PMC3345213
EDAT- 2012/05/12 06:00
MHDA- 2012/05/12 06:01
PMCR- 2012/04/19
CRDT- 2012/05/12 06:00
PHST- 2011/10/15 00:00 [received]
PHST- 2012/01/20 00:00 [accepted]
PHST- 2012/05/12 06:00 [entrez]
PHST- 2012/05/12 06:00 [pubmed]
PHST- 2012/05/12 06:01 [medline]
PHST- 2012/04/19 00:00 [pmc-release]
AID - 10.1155/2012/569728 [doi]
PST - ppublish
SO  - Autoimmune Dis. 2012;2012:569728. doi: 10.1155/2012/569728. Epub 2012 Apr 19.