PMID- 22580438
OWN - NLM
STAT- MEDLINE
DCOM- 20130319
LR  - 20181202
IS  - 1536-4798 (Electronic)
IS  - 0277-3740 (Linking)
VI  - 32
IP  - 1
DP  - 2013 Jan
TI  - Relationship between total tear IgE and specific serum IgE in autumnal allergic 
      conjunctivitis.
PG  - 14-9
LID - 10.1097/ICO.0b013e318253214b [doi]
AB  - PURPOSE: A new commercial immunochromatographic test (Allerwatch) has recently 
      been developed for determining total immunoglobulin E (IgE). We previously 
      reported on the use of this kit for analyzing tear fluid samples collected during 
      the spring. In this study, we examined the relationship between the total IgE 
      level in tears and the specific serum IgE levels in patients with autumnal 
      allergic conjunctivitis. METHODS: A prospective, nonrandomized cross-sectional 
      study was conducted in 36 patients with autumnal allergic conjunctivitis 
      (autumnal allergic group), in 32 age-matched and sex-matched healthy control 
      subjects (control group), and in 10 patients with epidemic keratoconjunctivitis. 
      Total tear IgE score was determined in all subjects using the Allerwatch test (0, 
      1, and 2), whereas the serum levels of total IgE and specific IgE for 12 inhaled 
      allergens were measured using the Phadezym PRIST and CAP-RAST systems, 
      respectively. RESULTS: Positivity rates for total tear IgE were significantly 
      higher in the autumnal allergic group as compared with the control and epidemic 
      keratoconjunctivitis groups (88.9% vs. 0.0% vs. 0.0%, P < 0.00001). In the 
      autumnal allergic group, there was a significant correlation between the total 
      tear IgE score and the log-transformed total serum IgE level (r = 0.84). 
      Significant correlations were also seen with the IgE serum levels for 
      Dermatophagoides pteronyssinus (r = 0.53), house dust (r = 0.51), acarus (r = 
      0.49), cedar pollen (r = 0.33), and mugwort (r = 0.33). Multivariate logistic 
      regression analysis showed that the only significant predictor of the total tear 
      IgE score was the log-transformed total serum IgE level (odds ratio = 2.76, P < 
      0.00001). CONCLUSIONS: The correlation between the Allerwatch total tear IgE 
      score and the specific IgE serum levels against house dust mites suggests that 
      house dust mite allergens might be the primary cause of allergic conjunctivitis 
      during autumn in Japan. The Allerwatch methodology can provide rapid measurements 
      of total IgE in the tear fluid, which makes it possible to easily diagnose 
      allergic conjunctivitis in an outpatient setting.
FAU - Mimura, Tatsuya
AU  - Mimura T
AD  - Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 
      Tokyo, Japan. mimurat-tky@umin.ac.jp
FAU - Usui, Tomohiko
AU  - Usui T
FAU - Yamagami, Satoru
AU  - Yamagami S
FAU - Miyai, Takashi
AU  - Miyai T
FAU - Amano, Shiro
AU  - Amano S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cornea
JT  - Cornea
JID - 8216186
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Allergens/immunology
MH  - Child
MH  - Chromatography, Affinity
MH  - Conjunctivitis, Allergic/*immunology
MH  - Cross-Sectional Studies
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Prospective Studies
MH  - Seasons
MH  - Sensitivity and Specificity
MH  - Skin Tests
MH  - Tears/*immunology
MH  - Young Adult
EDAT- 2012/05/15 06:00
MHDA- 2013/03/21 06:00
CRDT- 2012/05/15 06:00
PHST- 2012/05/15 06:00 [entrez]
PHST- 2012/05/15 06:00 [pubmed]
PHST- 2013/03/21 06:00 [medline]
AID - 10.1097/ICO.0b013e318253214b [doi]
PST - ppublish
SO  - Cornea. 2013 Jan;32(1):14-9. doi: 10.1097/ICO.0b013e318253214b.