PMID- 22580565
OWN - NLM
STAT- MEDLINE
DCOM- 20121204
LR  - 20220316
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Linking)
VI  - 61
IP  - 2
DP  - 2012 Oct 1
TI  - Adipogenic/lipid, inflammatory, and mitochondrial parameters in subcutaneous 
      adipose tissue of untreated HIV-1-infected long-term nonprogressors: significant 
      alterations despite low viral burden.
PG  - 131-7
AB  - BACKGROUND: HIV-1 can induce disturbances in adipose tissue in infected subjects 
      through the effects of some of its proteins or inflammation. It is not known 
      whether this also takes place in HIV-1-infected long-term nonprogressors (LTNPs). 
      Our objectives were to determine whether adipocyte differentiation/lipid, 
      inflammatory, and mitochondrial parameters are perturbed in abdominal wall 
      subcutaneous adipose tissue of untreated HIV-1-infected patients LTNPs. METHODS: 
      Cross-sectional study involving 10 LTNPs, 10 typical progressors (TPs), and 10 
      uninfected controls (UCs). The parameters assessed were peroxisome 
      proliferator-activated receptor-gamma (PPARgamma), lipoprotein lipase, and fatty 
      acid-binding protein 4 mRNA (adipogenic/lipid); tumor necrosis factor-alpha, 
      interleukin 18 (IL-18), beta2-MCG, monocyte chemoattractant protein 1, CD1A, and C3 
      mRNA (inflammation); and cytochrome c oxidase subunit II (COII), COIV, CYCA, 
      nuclear respiratory factor 1, PPARgamma coactivator 1alpha mRNA, and mtDNA content 
      (mitochondrial). RESULTS: Regarding adipogenic/lipid parameters, LTNPs had PPARgamma, 
      lipoprotein lipase, and fatty acid-binding protein 4 mRNA significantly decreased 
      compared with UCs (P </= 0.001 for all comparisons). PPARgamma mRNA was significantly 
      greater in LTNP than in TP (P = 0.006). With respect to inflammatory parameters, 
      tumor necrosis factor-alpha, IL-18, and beta2-MCG mRNA were significantly higher in 
      LTNPs compared with UCs (P < 0.005 for all comparisons), whereas IL-18 mRNA was 
      greater in TPs compared with LTNPs (P = 0.01). As mitochondrial parameters are 
      concerned, mtDNA was significantly reduced in LTNPs compared with TPs (P = 0.04) 
      and UCs (P = 0.03). COII and COIV were also significantly reduced in LTNPs 
      compared with UCs and TPs. CONCLUSIONS: Adipose tissue from untreated LTNPs may 
      have limited but significant derangements in some adipogenic/lipid and may have 
      inflammatory processes at a lower degree than that observed in untreated TPs. 
      LTNPs may have mitochondrial-related alterations in adipose tissue which are 
      greater than that observed in TPs.
FAU - Vidal, Francesc
AU  - Vidal F
AD  - Department of Internal Medicine, Hospital Universitari de Tarragona Joan XXIII, 
      IISPV, Universitat Rovira i Virgili, Tarragona, Spain. 
      fvidalmarsal.hj23.ics@gencat.cat
FAU - Domingo, Pere
AU  - Domingo P
FAU - Villarroya, Francesc
AU  - Villarroya F
FAU - Giralt, Marta
AU  - Giralt M
FAU - Lopez-Dupla, Miguel
AU  - Lopez-Dupla M
FAU - Gutierrez, Mar
AU  - Gutierrez M
FAU - Gallego-Escuredo, Jose M
AU  - Gallego-Escuredo JM
FAU - Peraire, Joaquim
AU  - Peraire J
FAU - Vilades, Consuelo
AU  - Vilades C
FAU - Veloso, Sergi
AU  - Veloso S
FAU - Mateo, Gracia
AU  - Mateo G
FAU - Guallar, Jordi P
AU  - Guallar JP
FAU - Richart, Cristobal
AU  - Richart C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (Cytokines)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Cytokines/*biosynthesis
MH  - Female
MH  - Gene Expression Profiling
MH  - HIV Infections/*pathology
MH  - *HIV Long-Term Survivors
MH  - Humans
MH  - *Lipid Metabolism
MH  - Male
MH  - Mitochondria/*physiology
MH  - Subcutaneous Fat/*pathology
MH  - Viral Load
EDAT- 2012/05/15 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/05/15 06:00
PHST- 2012/05/15 06:00 [entrez]
PHST- 2012/05/15 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - 10.1097/QAI.0b013e31825c3a68 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2012 Oct 1;61(2):131-7. doi: 
      10.1097/QAI.0b013e31825c3a68.