PMID- 22581868
OWN - NLM
STAT- MEDLINE
DCOM- 20120905
LR  - 20120514
IS  - 1758-1052 (Electronic)
IS  - 0956-4624 (Linking)
VI  - 23
IP  - 3
DP  - 2012 Mar
TI  - Identification of potential drug-drug interactions between antiretroviral drugs 
      from prescriptions in the private health-care sector in South Africa.
PG  - 166-72
LID - 10.1258/ijsa.2009.009343 [doi]
AB  - The aim of this study was to identify potential drug-drug interactions (DDIs) 
      between antiretroviral drugs (ARVs) and to determine whether prescribed daily 
      doses (PDDs) from prescriptions can be used in the evaluation of these 
      interactions. A quantitative, retrospective drug utilization study was performed 
      on 49,995 and 81,096 ARV prescriptions from a South African pharmacy benefit 
      management company, which were prescribed to 7664 and 10,162 HIV patients for 
      2005 and 2006, respectively. Potential DDIs identified across different age 
      groups were 778 for 2005 and 1155 for 2006; the majority occurred in patients 
      aged 19 to </=45 years. The potential DDIs identified between ARVs were all 
      interacting at clinical significance level 2 according to guidelines indicated by 
      Tatro. These results demonstrate that potential DDIs were identified between ARVs 
      mostly in three ARV combinations: Kaletra((R)) (lopinavir/ritonavir) and efavirenz, 
      lopinavir/ritonavir and nevirapine and combinations of indinavir and ritonavir. 
      There is a need for more education on the prescribing protocols for ARVs in the 
      treatment of HIV-infected patients in the private health-care sector in South 
      Africa.
FAU - Katende-Kyenda, N L
AU  - Katende-Kyenda NL
AD  - Department of Pharmacology, Walter Sisulu University, Mthatha, South Africa.
FAU - Lubbe, M S
AU  - Lubbe MS
FAU - Serfontein, J H P
AU  - Serfontein JH
FAU - Truter, I
AU  - Truter I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J STD AIDS
JT  - International journal of STD & AIDS
JID - 9007917
RN  - 0 (Anti-Retroviral Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anti-Retroviral Agents/*administration & dosage/*pharmacology
MH  - Antiretroviral Therapy, Highly Active/*methods
MH  - Child
MH  - Child, Preschool
MH  - *Drug Interactions
MH  - Drug Prescriptions/*statistics & numerical data
MH  - Drug Utilization/statistics & numerical data
MH  - Female
MH  - HIV Infections/*drug therapy
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Middle Aged
MH  - Private Practice/*statistics & numerical data
MH  - Retrospective Studies
MH  - South Africa
MH  - Young Adult
EDAT- 2012/05/15 06:00
MHDA- 2012/09/06 06:00
CRDT- 2012/05/15 06:00
PHST- 2012/05/15 06:00 [entrez]
PHST- 2012/05/15 06:00 [pubmed]
PHST- 2012/09/06 06:00 [medline]
AID - 23/3/166 [pii]
AID - 10.1258/ijsa.2009.009343 [doi]
PST - ppublish
SO  - Int J STD AIDS. 2012 Mar;23(3):166-72. doi: 10.1258/ijsa.2009.009343.