PMID- 22582923
OWN - NLM
STAT- MEDLINE
DCOM- 20130614
LR  - 20130102
IS  - 1600-0765 (Electronic)
IS  - 0022-3484 (Linking)
VI  - 48
IP  - 1
DP  - 2013 Feb
TI  - Role of high endothelial postcapillary venules and selected adhesion molecules in 
      periodontal diseases: a review.
PG  - 1-21
LID - 10.1111/j.1600-0765.2012.01492.x [doi]
AB  - Periodontitis is accompanied by the proliferation of small blood vessels in the 
      gingival lamina propria. Specialized postcapillary venules, termed periodontal 
      high endothelial-like venules, are also present, and demonstrate morphological 
      and functional traits similar to those of high endothelial venules (HEVs) in 
      lymphatic organs. The suggested role of HEVs in the pathogenesis of chronic 
      periodontitis involves participation in leukocyte transendothelial migration and 
      therefore proinflammatory effects appear. Recent observations suggest that 
      chronic periodontitis is an independent risk factor for systemic vascular disease 
      and may result in stimulation of the synthesis of acute phase protein by 
      cytokines released by periodontal high endothelial cells (HECs). However, tissue 
      expression of HEV-linked adhesion molecules has not been evaluated in the gingiva 
      of patients with chronic periodontitis. This is significant in relation to 
      potential therapy targeting expression of the adhesion molecules. In this review, 
      current knowledge of HEV structure and the related expression of four surface 
      adhesion molecules of HECs [CD34, platelet endothelial cell adhesion molecule 1, 
      endoglin and intercellular adhesion molecule 1 (ICAM-1)], involved in the key 
      steps of the adhesion cascade in periodontal diseases, are discussed. Most 
      studies on the expression of adhesion molecules in the development and 
      progression of periodontal diseases pertain to ICAM-1 (CD54). Studies by the 
      authors demonstrated quantitatively similar expression of three of four selected 
      surface markers in gingival HEVs of patients with chronic periodontitis and in 
      HEVs of reactive lymph nodes, confirming morphological and functional similarity 
      of HEVs in pathologically altered tissues with those in lymphoid tissues.
CI  - (c) 2012 John Wiley & Sons A/S.
FAU - Kasprzak, A
AU  - Kasprzak A
AD  - Department of Histology and Embryology, Poznan University of Medical Sciences, 
      Poznan, Poland. akasprza@ump.edu.pl
FAU - Surdacka, A
AU  - Surdacka A
FAU - Tomczak, M
AU  - Tomczak M
FAU - Konkol, M
AU  - Konkol M
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20120514
PL  - United States
TA  - J Periodontal Res
JT  - Journal of periodontal research
JID - 0055107
RN  - 0 (Cell Adhesion Molecules)
SB  - IM
MH  - Capillaries/physiology
MH  - Cell Adhesion Molecules/*physiology
MH  - Chronic Periodontitis/*pathology
MH  - Endothelial Cells/pathology
MH  - Endothelium, Lymphatic/pathology
MH  - Endothelium, Vascular/pathology
MH  - Gingiva/blood supply
MH  - Humans
MH  - Transendothelial and Transepithelial Migration/physiology
MH  - Venules/*physiology
EDAT- 2012/05/16 06:00
MHDA- 2013/06/15 06:00
CRDT- 2012/05/16 06:00
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2013/06/15 06:00 [medline]
AID - 10.1111/j.1600-0765.2012.01492.x [doi]
PST - ppublish
SO  - J Periodontal Res. 2013 Feb;48(1):1-21. doi: 10.1111/j.1600-0765.2012.01492.x. 
      Epub 2012 May 14.