PMID- 22583431
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20231111
IS  - 1996-3181 (Electronic)
IS  - 1871-5273 (Print)
IS  - 1871-5273 (Linking)
VI  - 11
IP  - 4
DP  - 2012 Jun 1
TI  - Alzheimer's disease and type 2 diabetes: exploring the association to obesity and 
      tyrosine hydroxylase.
PG  - 482-9
AB  - Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are two debilitating 
      health disorders afflicting millions worldwide. Recent research has revealed 
      similarities between AD and T2DM. Both these protein conformational disorders are 
      associated with obesity, insulin resistance, inflammation and endoplasmic 
      reticulum stress, en-route initiation and/or stage aggravation. In this mini 
      review we have tried to summarize studies describing obesity, insulin resistance 
      and glucocorticoid imbalance as common patho-mechanisms in T2DM and AD. A 
      reduction in tyrosine hydroxylase (TH) in the brain has been found to occur in 
      Parkinson's disease (PD). AD, T2DM and PD share common risk factors like 
      depression. Thus, whether TH is involved in the 'state of cognitive depression' 
      that is the hallmark of AD and often accompanies PD and T2DM is also explored.
FAU - Priyadarshini, Medha
AU  - Priyadarshini M
AD  - Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, 
      UP, India. medha.priyadarshini@gmail.com
FAU - Kamal, Mohammad A
AU  - Kamal MA
FAU - Greig, Nigel H
AU  - Greig NH
FAU - Reale, Marcella
AU  - Reale M
FAU - Abuzenadah, Adel M
AU  - Abuzenadah AM
FAU - Chaudhary, Adeel G A
AU  - Chaudhary AG
FAU - Damanhouri, Ghazi A
AU  - Damanhouri GA
LA  - eng
GR  - Z01 AG000311-07/ImNIH/Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United Arab Emirates
TA  - CNS Neurol Disord Drug Targets
JT  - CNS & neurological disorders drug targets
JID - 101269155
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
SB  - IM
MH  - Alzheimer Disease/*enzymology/etiology
MH  - Animals
MH  - Brain/metabolism
MH  - Diabetes Mellitus, Type 2/*enzymology/etiology
MH  - Humans
MH  - Obesity/complications/*enzymology
MH  - Parkinson Disease/complications/enzymology
MH  - Tyrosine 3-Monooxygenase/*metabolism
PMC - PMC5002347
MID - NIHMS738734
COIS- The authors declare that they have no conflicts of interest.
EDAT- 2012/05/16 06:00
MHDA- 2012/12/10 06:00
PMCR- 2016/08/28
CRDT- 2012/05/16 06:00
PHST- 2012/02/22 00:00 [received]
PHST- 2012/04/11 00:00 [revised]
PHST- 2012/04/12 00:00 [accepted]
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
PHST- 2016/08/28 00:00 [pmc-release]
AID - CDTCNSND-EPUB-20120511-4 [pii]
AID - 10.2174/187152712800792767 [doi]
PST - ppublish
SO  - CNS Neurol Disord Drug Targets. 2012 Jun 1;11(4):482-9. doi: 
      10.2174/187152712800792767.