PMID- 22583598
OWN - NLM
STAT- MEDLINE
DCOM- 20121012
LR  - 20220321
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 11
DP  - 2012 Jul 16
TI  - Gender difference in carotid intima-media thickness in type 2 diabetic patients: 
      a 4-year follow-up study.
PG  - 51
LID - 10.1186/1475-2840-11-51 [doi]
AB  - BACKGROUND: Different population studies have reported gender difference in 
      carotid intima-media thickness (CIMT), which is proved to be a risk factor of 
      cardiovascular diseases. However, few longitudinal researches examine this gender 
      difference in type 2 diabetes mellitus (T2DM) patients. Therefore, we 
      prospectively analyzed CIMT in T2DM patients over a 4-year follow-up period. 
      METHODS: 355 T2DM patients (mean age 59 years; 54.9% women) were included in the 
      present study. CIMT were measured using Color Doppler ultrasound. CIMT was 
      measured at baseline (CIMT) in 2006 and at follow-up in 2010. Biochemical and 
      clinical measurements were collected at baseline. RESULTS: Mean value of CIMT1 
      and CIMT2 were 0.740 +/- 0.148 mm and 0.842 +/- 0.179 mm, respectively. Men had 
      higher CIMT than women both at baseline and at follow-up (CIMT1: 0.762 +/- 0.149 vs 
      0.723 +/- 0.146 mm, P = 0.0149; CIMT2: 0.880 +/- 0.189 vs 0.810 +/- 0.164 mm, 
      P = 0.0002). Mean annual progression of CIMT (dCIMT) was 0.025 +/- 0.022 mm/year. 
      dCIMT was larger in men than in women (0.030 +/- 0.025 vs 0.022 +/- 0.019 mm, 
      P = 0.0006). In multiple regression analyses, age was an independent risk factor 
      of CIMT in both genders, while dCIMT was associated with age only in men. 
      CONCLUSIONS: Gender difference in CIMT was confirmed in T2DM patients. Moreover, 
      impact of ageing on CIMT progression only existed in men, which might be the 
      reason that gender difference in CIMT increased with age.
FAU - Zhao, Bo
AU  - Zhao B
AD  - Department of Ultrasonography, Ruijin Hospital, Shanghai Jiaotong University 
      Medical School, 197 Ruijin 2nd Road, Shanghai 200025, People's Republic of China.
FAU - Liu, Yanping
AU  - Liu Y
FAU - Zhang, Yifei
AU  - Zhang Y
FAU - Chen, Yuhong
AU  - Chen Y
FAU - Yang, Zhifang
AU  - Yang Z
FAU - Zhu, Ying
AU  - Zhu Y
FAU - Zhan, Weiwei
AU  - Zhan W
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20120716
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Carotid Artery Diseases/*diagnostic imaging/etiology
MH  - *Carotid Intima-Media Thickness
MH  - Chi-Square Distribution
MH  - China
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Diabetic Angiopathies/*diagnostic imaging/etiology
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sex Factors
MH  - Time Factors
MH  - *Ultrasonography, Doppler, Color
PMC - PMC3398844
EDAT- 2012/05/16 06:00
MHDA- 2012/10/13 06:00
PMCR- 2012/07/16
CRDT- 2012/05/16 06:00
PHST- 2012/03/18 00:00 [received]
PHST- 2012/05/14 00:00 [accepted]
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/10/13 06:00 [medline]
PHST- 2012/07/16 00:00 [pmc-release]
AID - 1475-2840-11-51 [pii]
AID - 10.1186/1475-2840-11-51 [doi]
PST - epublish
SO  - Cardiovasc Diabetol. 2012 Jul 16;11:51. doi: 10.1186/1475-2840-11-51.