PMID- 22583767
OWN - NLM
STAT- MEDLINE
DCOM- 20121221
LR  - 20131121
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 523
IP  - 1
DP  - 2012 Aug 8
TI  - Acidic preconditioning protects against ischemia-induced brain injury.
PG  - 3-8
LID - 10.1016/j.neulet.2012.05.015 [doi]
AB  - Ischemic preconditioning protects against cerebral ischemia. Recent 
      investigations indicated that acidic preconditioning (APC) protects against 
      ischemia-induced cardiomyocytes injury. However, it is not clear whether APC can 
      protect against cerebral ischemia. To address this issue, C57BL/6 mice were 
      exposed 3 times at 10-min intervals to a normoxic atmosphere containing 20% CO(2) 
      for 5 min before being further subjected to bilateral common carotid artery 
      occlusion. APC reversed the ischemia-induced brain injury as revealed by improved 
      performance in passive avoidance experiments and decreased neuron loss in the 
      hippocampal CA1 region. Consistently, both APC-treated brain slices and primary 
      cultured neurons were more resistant to oxygen-glucose-deprivation (OGD)-induced 
      injury, in a pH- and time-dependent manner, as revealed by reversed cell/tissue 
      viability. In addition, the APC treatment prevented OGD-induced mitochondrial 
      transmembrane potential loss and apoptosis, which was inhibited by the 
      mitochondrial permeability transport pore opener atractyloside. Taken together, 
      these findings indicated that APC protects against ischemia-induced neuronal 
      injury. The beneficial effects may be attributed, at least in part, to decreased 
      mitochondria-dependent neuronal apoptosis.
CI  - Copyright (c) 2012 Elsevier Ireland Ltd. All rights reserved.
FAU - Zhang, Chen-hui
AU  - Zhang CH
AD  - Zhejiang Provincial Key Laboratory of Medical Genetics, School of Life Sciences, 
      Wenzhou Medical College, Wenzhou 325035, China.
FAU - Fan, Yan-ying
AU  - Fan YY
FAU - Wang, Xiao-fen
AU  - Wang XF
FAU - Xiong, Jia-yan
AU  - Xiong JY
FAU - Tang, Ying-ying
AU  - Tang YY
FAU - Gao, Jie-qiong
AU  - Gao JQ
FAU - Shen, Zhe
AU  - Shen Z
FAU - Song, Xiao-hui
AU  - Song XH
FAU - Zhang, Jing-ying
AU  - Zhang JY
FAU - Shen, Yao
AU  - Shen Y
FAU - Li, Qing
AU  - Li Q
FAU - Zhang, Xiangnan
AU  - Zhang X
FAU - Chen, Zhong
AU  - Chen Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120511
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
CIN - Neurosci Lett. 2012 Aug 8;523(1):1-2. PMID: 22743297
MH  - Acidosis
MH  - Animals
MH  - Brain Chemistry/*drug effects
MH  - Brain Injuries/diagnosis/*physiopathology/*therapy
MH  - Brain Ischemia/diagnosis/*physiopathology/*therapy
MH  - Carbon Dioxide/*administration & dosage
MH  - Hydrogen-Ion Concentration/drug effects
MH  - Ischemic Preconditioning/*methods
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Treatment Outcome
EDAT- 2012/05/16 06:00
MHDA- 2012/12/22 06:00
CRDT- 2012/05/16 06:00
PHST- 2012/03/16 00:00 [received]
PHST- 2012/04/30 00:00 [revised]
PHST- 2012/05/02 00:00 [accepted]
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/12/22 06:00 [medline]
AID - S0304-3940(12)00651-9 [pii]
AID - 10.1016/j.neulet.2012.05.015 [doi]
PST - ppublish
SO  - Neurosci Lett. 2012 Aug 8;523(1):3-8. doi: 10.1016/j.neulet.2012.05.015. Epub 
      2012 May 11.