PMID- 22584108
OWN - NLM
STAT- MEDLINE
DCOM- 20121106
LR  - 20131121
IS  - 1095-6867 (Electronic)
IS  - 0018-506X (Linking)
VI  - 62
IP  - 1
DP  - 2012 Jun
TI  - Recurrent long-lasting tethering reduces BDNF protein levels in the dorsal 
      hippocampus and frontal cortex in pigs.
PG  - 10-7
LID - 10.1016/j.yhbeh.2012.04.019 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) signaling has been implicated in the 
      onset of depression and in antidepressant efficacy, although the exact role of 
      this neurotrophin in the pathophysiology of depression remains to be elucidated. 
      Also, the interaction between chronic stress, which may precede depression, 
      corticosteroids and BDNF is not fully understood. The present study aimed at 
      investigating whether long-lasting, recurrent tethering of sows during a period 
      of 1.5 or 4.5 years leads to enduring effects on measures that may be indicative 
      of chronic stress, compared with animals kept in a group housing system ('loose' 
      sows). Immediately after slaughter, the frontal cortex, dorsal and ventral 
      hippocampus were dissected and protein levels of BDNF and its receptors were 
      analyzed and compared with plasma cortisol levels and adrenal weights. Results 
      indicate that tethering stress reduced BDNF protein levels in the dorsal 
      hippocampus and the frontal cortex, but not in the ventral hippocampus. In 
      addition, levels of TrkB, the high affinity receptor for BDNF, were increased in 
      the dorsal hippocampus. Plasma cortisol levels and adrenal weight were increased 
      after tethering. These stress effects on BDNF levels were more pronounced after 
      4.5 years of recurrent tethering and negatively correlated in particular in the 
      frontal cortex with cortisol levels and adrenal weight. This suggests that the 
      stress effect of tethered housing on neurotrophin levels may be mediated via 
      cortisol. Taken together, these data indicate that recurrent tethering stress in 
      sows over 4.5 years results in a loss of neurotrophic support by BDNF, mediated 
      by an overactive neuroendocrine system.
CI  - Copyright (c) 2012 Elsevier Inc. All rights reserved.
FAU - De Vry, J
AU  - De Vry J
AD  - Department of Psychiatry and Neuropsychology, School for Mental Health and 
      Neuroscience, European Graduate School of Neuroscience (EURON), Maastricht 
      University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands.
FAU - Prickaerts, J
AU  - Prickaerts J
FAU - Jetten, M
AU  - Jetten M
FAU - Hulst, M
AU  - Hulst M
FAU - Steinbusch, H W M
AU  - Steinbusch HW
FAU - van den Hove, D L A
AU  - van den Hove DL
FAU - Schuurman, T
AU  - Schuurman T
FAU - van der Staay, F J
AU  - van der Staay FJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120511
PL  - United States
TA  - Horm Behav
JT  - Hormones and behavior
JID - 0217764
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adrenal Glands/anatomy & histology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Depression/metabolism/psychology
MH  - Disease Models, Animal
MH  - Female
MH  - Frontal Lobe/*metabolism
MH  - Hippocampus/*metabolism
MH  - Hydrocortisone/blood
MH  - Receptor, trkB/analysis
MH  - Stress, Psychological/*metabolism
MH  - Swine/metabolism/psychology
EDAT- 2012/05/16 06:00
MHDA- 2012/11/07 06:00
CRDT- 2012/05/16 06:00
PHST- 2011/12/19 00:00 [received]
PHST- 2012/03/19 00:00 [revised]
PHST- 2012/04/14 00:00 [accepted]
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/11/07 06:00 [medline]
AID - S0018-506X(12)00142-0 [pii]
AID - 10.1016/j.yhbeh.2012.04.019 [doi]
PST - ppublish
SO  - Horm Behav. 2012 Jun;62(1):10-7. doi: 10.1016/j.yhbeh.2012.04.019. Epub 2012 May 
      11.