PMID- 22584531
OWN - NLM
STAT- MEDLINE
DCOM- 20121228
LR  - 20240330
IS  - 1129-2377 (Electronic)
IS  - 1129-2369 (Print)
IS  - 1129-2369 (Linking)
VI  - 13
IP  - 6
DP  - 2012 Aug
TI  - Brain-derived neurotrophic factor in primary headaches.
PG  - 469-75
LID - 10.1007/s10194-012-0454-5 [doi]
AB  - Brain derived neurotrophic factor (BDNF) is associated with pain modulation and 
      central sensitization. Recently, a role of BDNF in migraine and cluster headache 
      pathophysiology has been suspected due to its known interaction with calcitonin 
      gene-related peptide. Bi-center prospective study was done enrolling four 
      diagnostic groups: episodic migraine with and without aura, episodic cluster 
      headache, frequent episodic tension-type headache, and healthy individuals. In 
      migraineurs, venous blood samples were collected twice: outside and during 
      migraine attacks prior to pain medication. In cluster headache patients serum 
      samples were collected in and outside cluster bout. Analysis of BDNF was 
      performed using enzyme-linked immunosorbent assay technique. Migraine patients 
      revealed significantly higher BDNF serum levels during migraine attacks (n = 25) 
      compared with headache-free intervals (n = 53, P < 0.01), patients with 
      tension-type headache (n = 6, P < 0.05), and healthy controls (n = 22, 
      P < 0.001). There was no significant difference between patients with migraine 
      with aura compared with those without aura, neither during migraine attacks nor 
      during headache-free periods. Cluster headache patients showed significantly 
      higher BDNF concentrations inside (n = 42) and outside cluster bouts (n = 24) 
      compared with healthy controls (P < 0.01, P < 0.05). BDNF is increased during 
      migraine attacks, and in cluster headache, further supporting the involvement of 
      BDNF in the pathophysiology of these primary headaches.
FAU - Fischer, Marlene
AU  - Fischer M
AD  - Department of Neurology, Headache Outpatient Clinic, Innsbruck Medical 
      University, Anichstrasse 35, 6020, Innsbruck, Austria. 
      marlene.fischer@i-med.ac.at
FAU - Wille, Georg
AU  - Wille G
FAU - Klien, Stephanie
AU  - Klien S
FAU - Shanib, Hind
AU  - Shanib H
FAU - Holle, Dagny
AU  - Holle D
FAU - Gaul, Charly
AU  - Gaul C
FAU - Broessner, Gregor
AU  - Broessner G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120515
PL  - England
TA  - J Headache Pain
JT  - The journal of headache and pain
JID - 100940562
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (brain-derived growth factor)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Headache/*blood/classification
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Migraine Disorders/blood
MH  - Prospective Studies
MH  - Statistics, Nonparametric
MH  - Young Adult
PMC - PMC3464472
EDAT- 2012/05/16 06:00
MHDA- 2012/12/29 06:00
PMCR- 2012/05/15
CRDT- 2012/05/16 06:00
PHST- 2012/02/26 00:00 [received]
PHST- 2012/04/18 00:00 [accepted]
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/12/29 06:00 [medline]
PHST- 2012/05/15 00:00 [pmc-release]
AID - 454 [pii]
AID - 10.1007/s10194-012-0454-5 [doi]
PST - ppublish
SO  - J Headache Pain. 2012 Aug;13(6):469-75. doi: 10.1007/s10194-012-0454-5. Epub 2012 
      May 15.