PMID- 2258536
OWN - NLM
STAT- MEDLINE
DCOM- 19910129
LR  - 20190907
IS  - 0731-5724 (Print)
IS  - 0731-5724 (Linking)
VI  - 9
IP  - 5
DP  - 1990 Oct
TI  - Antiarrhythmic short-term protective magnesium treatment in ischemic dilated 
      cardiomyopathy.
PG  - 492-9
AB  - The efficacy of magnesium sulfate (MgSO4) infusion in the treatment of 
      ventricular arrhythmias was evaluated in 10 normomagnesemic patients: seven men 
      and three women, aged 56-78 years (mean +/- SD, 63.8 +/- 9.3). All of the 
      patients had ischemic dilated cardiomyopathy (IDC) and severe ventricular 
      arrhythmias: multiform ventricular premature contractions (VPCs), couplets, runs 
      of ventricular tachycardia (VT), and R-on-T phenomenon. Four had evidence of old 
      myocardial infarction (MI), four had chronic ischemic cardiomyopathy, and two had 
      effort angina pectoris. Dilated cardiomyopathy was diagnosed by chest X-ray 
      (cardiothoracic ratio greater than 0.5) and echocardiogram (end-diastolic 
      left-ventricular diameter greater than 56 mm). All of the patients underwent two 
      successive 24-hr Holter monitoring at the time of admission and after 3, 5, and 
      10 days from the beginning of therapy. Ventricular arrhythmias were classified 
      according to modified Lown criteria. Renal function was normal. Magnesium sulfate 
      in 0.9% sodium chloride was given by slow infusions (50 mg/min/60 min) twice 
      daily for 7 days. They were antiarrhythmic in all of the patients: VPCs and 
      couplets mean values decreased from 7971 +/- 2612 to 321 +/- 141 (p less than 
      0.001) and from 405 +/- 113 to 7 +/- 4 (p less than 0.001), respectively; VT runs 
      (33.8 +/- 5.8) disappeared by the fifth day of treatment. Both the heart rate and 
      the QTc interval remained unchanged from baseline values. The slow magnesium 
      infusion did not notably raise serum Mg when evaluated immediately after stopping 
      the infusion, as compared with baseline values.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Perticone, F
AU  - Perticone F
AD  - Department of Medicina Sperimentale e Clinica, School of Medicine, Catanzaro, 
      University of Reggio Calabria, Italy.
FAU - Borelli, D
AU  - Borelli D
FAU - Ceravolo, R
AU  - Ceravolo R
FAU - Mattioli, P L
AU  - Mattioli PL
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Coll Nutr
JT  - Journal of the American College of Nutrition
JID - 8215879
RN  - 7487-88-9 (Magnesium Sulfate)
SB  - IM
MH  - Aged
MH  - Cardiomyopathy, Dilated/*complications
MH  - Electrocardiography, Ambulatory
MH  - Female
MH  - Heart Ventricles
MH  - Humans
MH  - Magnesium Sulfate/*therapeutic use
MH  - Male
MH  - Middle Aged
MH  - Tachycardia/*drug therapy/physiopathology
MH  - Time Factors
EDAT- 1990/10/01 00:00
MHDA- 1990/10/01 00:01
CRDT- 1990/10/01 00:00
PHST- 1990/10/01 00:00 [pubmed]
PHST- 1990/10/01 00:01 [medline]
PHST- 1990/10/01 00:00 [entrez]
AID - 10.1080/07315724.1990.10720406 [doi]
PST - ppublish
SO  - J Am Coll Nutr. 1990 Oct;9(5):492-9. doi: 10.1080/07315724.1990.10720406.