PMID- 22586056
OWN - NLM
STAT- MEDLINE
DCOM- 20120712
LR  - 20230718
IS  - 1943-7722 (Electronic)
IS  - 0002-9173 (Linking)
VI  - 137
IP  - 6
DP  - 2012 Jun
TI  - Solitary fibrous tumor: is there a molecular relationship with cellular 
      angiofibroma, spindle cell lipoma, and mammary-type myofibroblastoma?
PG  - 963-70
LID - 10.1309/AJCPQEG6YNN6CNAL [doi]
AB  - Solitary fibrous tumor (SFT) is a mesenchymal tumor characterized by ovoid cells, 
      branching blood vessels, stromal hyalinization, and CD34 immunoreactivity. 
      Studies have shown loss of 13q in a group of morphologically similar entities, 
      including cellular angiofibroma, mammary-type myofibroblastoma, and spindle cell 
      lipoma. The histologic and immunophenotypic overlap between SFT and the latter 
      group of tumors suggests that these tumors may be genetically linked. We tested a 
      group of 40 SFTs to assess for loss of RB1 (13q14) by fluorescence in situ 
      hybridization (FISH). All 38 SFTs with evaluable signals failed to show loss of 
      RB1 (13q14) by FISH. All cases of cellular angiofibroma (1/1), spindle cell 
      lipoma (6/6), and mammary-type myofibroblastoma (4/4), which were used as a 
      control group, showed monoallelic or biallelic loss of RB1. The absence of RB1 
      loss in SFTs suggests that they are not related to cellular angiofibroma, 
      mammary-type myofibroblastoma, or spindle cell lipoma.
FAU - Fritchie, Karen J
AU  - Fritchie KJ
AD  - Departments of L aboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 
      55905, USA.
FAU - Carver, Paula
AU  - Carver P
FAU - Sun, Yang
AU  - Sun Y
FAU - Batiouchko, Galina
AU  - Batiouchko G
FAU - Billings, Steven D
AU  - Billings SD
FAU - Rubin, Brian P
AU  - Rubin BP
FAU - Tubbs, Raymond R
AU  - Tubbs RR
FAU - Goldblum, John R
AU  - Goldblum JR
LA  - eng
PT  - Journal Article
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (Antigens, CD34)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Retinoblastoma Protein)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angiofibroma/genetics/pathology
MH  - Antigens, CD34/immunology
MH  - Biomarkers, Tumor/*genetics
MH  - Breast/pathology
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Lipoma/genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasms, Muscle Tissue/genetics/pathology
MH  - Retinoblastoma Protein/*genetics
MH  - Solitary Fibrous Tumors/*diagnosis/*genetics/pathology
EDAT- 2012/05/16 06:00
MHDA- 2012/07/13 06:00
CRDT- 2012/05/16 06:00
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/07/13 06:00 [medline]
AID - 137/6/963 [pii]
AID - 10.1309/AJCPQEG6YNN6CNAL [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2012 Jun;137(6):963-70. doi: 10.1309/AJCPQEG6YNN6CNAL.