PMID- 2258631
OWN - NLM
STAT- MEDLINE
DCOM- 19910129
LR  - 20190723
IS  - 0022-202X (Print)
IS  - 0022-202X (Linking)
VI  - 95
IP  - 6 Suppl
DP  - 1990 Dec
TI  - Response of discoid and subacute cutaneous lupus erythematosus to recombinant 
      interferon alpha 2a.
PG  - 142S-145S
AB  - Ten patients suffering from discoid lupus erythematosus (DLE) or subacute 
      cutaneous lupus erythematosus (SCLE) were treated with interferon alpha 2a. A 
      marked improvement or clearing of cutaneous lupus erythematosus lesions was 
      observed in eight of them. However, the response to interferon was of short 
      duration and within a few weeks after interferon withdrawal all patients who were 
      improved or cleared relapsed. This study suggests that interferon alpha 2a 
      represents a new interesting approach in the treatment of DLE and SCLE. Ongoing 
      trials will define the optimal treatment schedule for the maintenance of 
      interferon-induced improvement of cutaneous lupus erythematosus.
FAU - Nicolas, J F
AU  - Nicolas JF
AD  - Clinique Dermatologique, Lyon, France.
FAU - Thivolet, J
AU  - Thivolet J
FAU - Kanitakis, J
AU  - Kanitakis J
FAU - Lyonnet, S
AU  - Lyonnet S
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Invest Dermatol
JT  - The Journal of investigative dermatology
JID - 0426720
RN  - 0 (Interferon alpha-2)
RN  - 0 (Interferon-alpha)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - Interferon alpha-2
MH  - Interferon-alpha/administration & dosage/*therapeutic use
MH  - Lupus Erythematosus, Cutaneous/*drug therapy/pathology
MH  - Lupus Erythematosus, Discoid/*drug therapy/pathology
MH  - Recombinant Proteins
MH  - Time Factors
EDAT- 1990/12/01 00:00
MHDA- 1990/12/01 00:01
CRDT- 1990/12/01 00:00
PHST- 1990/12/01 00:00 [pubmed]
PHST- 1990/12/01 00:01 [medline]
PHST- 1990/12/01 00:00 [entrez]
AID - 0022-202X(90)91208-S [pii]
AID - 10.1111/1523-1747.ep12875049 [doi]
PST - ppublish
SO  - J Invest Dermatol. 1990 Dec;95(6 Suppl):142S-145S. doi: 
      10.1111/1523-1747.ep12875049.