PMID- 22586497
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20211021
IS  - 2005-6168 (Electronic)
IS  - 1976-1457 (Print)
IS  - 1976-1457 (Linking)
VI  - 6
IP  - 2
DP  - 2012 Apr
TI  - Suppressive effects of Schizandra chinensis Baillon water extract on 
      allergy-related cytokine generation and degranulation in IgE-antigen 
      complex-stimulated RBL-2H3 cells.
PG  - 97-105
LID - 10.4162/nrp.2012.6.2.97 [doi]
AB  - Schizandra chinensis Baillon is a traditional folk medicine plant that is used to 
      treat and prevent several inflammatory diseases and cancer in Korea, but the 
      underlying mechanisms involved in its anti-allergic activity are not fully 
      understood. This study was designed to investigate mechanisms of anti-allergic 
      activity of a Schizandra chinensis Baillon water extract (SCWE) in immunoglobulin 
      E (IgE)-antigen complex-stimulated RBL2H3 cells and to assess whether gastric and 
      intestinal digestion affects the anti-allergic properties of SCWE. Oxidative 
      stress is an important consequence of the allergic inflammatory response. The 
      antioxidant activities of SCWE increased in a concentration-dependent manner. 
      RBL-2H3 cells were sensitized with monoclonal anti-dinitrophenol (DNP) specific 
      IgE, treated with SCWE, and challenged with the antigen DNP-human serum albumin. 
      SCWE inhibited beta-hexosaminidase release and expression of interleukin (IL)-4, 
      IL-13, and tumor necrosis factor-alpha (TNF-alpha) mRNA and protein in IgE-antigen 
      complex-stimulated RBL2H3 cells. We found that digested SCWE fully maintained its 
      antioxidant activity and anti-allergic activity against the IgE-antigen 
      complex-induced activation of RBL-2H3 cells. SCWE may be useful for preventing 
      allergic diseases, such as asthma. Thus, SCWE could be used as a natural 
      functional ingredient for allergic diseases in the food and/or pharmaceutical 
      industries.
FAU - Chung, Mi Ja
AU  - Chung MJ
AD  - The Nutraceutical Bio Brain Korea 21 Project Group, Kangwon National University, 
      Chuncheon 200-701, Korea.
FAU - Kim, Jeong-Mi
AU  - Kim JM
FAU - Lee, Sangchul
AU  - Lee S
FAU - Kim, Taewoo
AU  - Kim T
FAU - Kim, Daejung
AU  - Kim D
FAU - Baek, Jongmi
AU  - Baek J
FAU - Kim, Taehyuk
AU  - Kim T
FAU - Lee, Jaesung
AU  - Lee J
FAU - Kim, Kyoungkon
AU  - Kim K
FAU - Yoon, Jin A
AU  - Yoon JA
FAU - Choe, Myeon
AU  - Choe M
LA  - eng
PT  - Journal Article
DEP - 20120430
PL  - Korea (South)
TA  - Nutr Res Pract
JT  - Nutrition research and practice
JID - 101311052
EIN - Nutr Res Pract. 2012 Jun;6(3):270
PMC - PMC3349042
OTO - NOTNLM
OT  - Allergic diseases
OT  - RBL-2H3 cells
OT  - Schizandra chinensis Baillon
OT  - antioxidant
OT  - cytokine
EDAT- 2012/05/16 06:00
MHDA- 2012/05/16 06:01
PMCR- 2012/04/01
CRDT- 2012/05/16 06:00
PHST- 2011/07/27 00:00 [received]
PHST- 2012/01/04 00:00 [revised]
PHST- 2012/02/01 00:00 [accepted]
PHST- 2012/05/16 06:00 [entrez]
PHST- 2012/05/16 06:00 [pubmed]
PHST- 2012/05/16 06:01 [medline]
PHST- 2012/04/01 00:00 [pmc-release]
AID - 10.4162/nrp.2012.6.2.97 [doi]
PST - ppublish
SO  - Nutr Res Pract. 2012 Apr;6(2):97-105. doi: 10.4162/nrp.2012.6.2.97. Epub 2012 Apr 
      30.