PMID- 22587575
OWN - NLM
STAT- MEDLINE
DCOM- 20120917
LR  - 20191210
IS  - 1520-5118 (Electronic)
IS  - 0021-8561 (Linking)
VI  - 60
IP  - 22
DP  - 2012 Jun 6
TI  - Development of multiresidue analysis for twenty phthalate esters in edible 
      vegetable oils by microwave-assisted extraction-gel permeation 
      chromatography-solid phase extraction-gas chromatography-tandem mass 
      spectrometry.
PG  - 5532-9
LID - 10.1021/jf3009603 [doi]
AB  - A novel multiresidue analysis method is developed for the determination of twenty 
      phthalate esters at the mug/kg level in edible vegetable oils by 
      microwave-assisted extraction-gel permeation chromatography-solid phase 
      extraction-high resolution gas chromatography-tandem mass spectrometry 
      (MAE-GPC-SPE-HRGC-MS/MS). The samples were extracted with methanol under 
      microwave incubation. Cleanup was carried out with GPC followed by a further C18 
      SPE column and then separated by the HP-5MS capillary column under a temperature 
      program. The eluents were qualitatively and quantitatively determined by tandem 
      mass analyzer with selected reaction monitoring (SRM) type and positive ion mode. 
      The calibration curves showed good linearity in the range 5 mug/kg to 2.50 mg/kg 
      with correlation coefficients larger than 0.999. Low detection limits (LODs) of 
      0.218-1.367 mug/kg and quantification limits (LOQ) of 0.72-4.51 mug/kg were 
      achieved. The mean recoveries were in the range from 93.04% to 104.6% at 5, 15, 
      and 40 mug/kg spiked levels, and the relative standard deviations (RSDs) were in 
      the range of 1.01% and 5.26% (n = 7). This method could potentially overcome the 
      interference from large amounts of lipids and pigment. The real sample test 
      showed this method can be used for sensitive and accurate determination and 
      confirmation of phthalate ester residues in high-fat and complex samples.
FAU - Sun, Hanwen
AU  - Sun H
AD  - College of Chemistry and Environmental Science, Hebei University, Key Laboratory 
      of Analytical Science and Technology of Hebei Province, Baoding, China. 
      hanwen@hbu.cn
FAU - Yang, Yanlei
AU  - Yang Y
FAU - Li, Hui
AU  - Li H
FAU - Zhang, Jingxuan
AU  - Zhang J
FAU - Sun, Na
AU  - Sun N
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120525
PL  - United States
TA  - J Agric Food Chem
JT  - Journal of agricultural and food chemistry
JID - 0374755
RN  - 0 (Esters)
RN  - 0 (Phthalic Acids)
RN  - 0 (Plant Oils)
RN  - 6O7F7IX66E (phthalic acid)
SB  - IM
MH  - Chromatography, Gel/*methods
MH  - Esters/*analysis/isolation & purification
MH  - Gas Chromatography-Mass Spectrometry/*methods
MH  - Microwaves
MH  - Phthalic Acids/*analysis/isolation & purification
MH  - Plant Oils/*analysis
MH  - Solid Phase Extraction/*methods
MH  - Tandem Mass Spectrometry/methods
EDAT- 2012/05/17 06:00
MHDA- 2012/09/18 06:00
CRDT- 2012/05/17 06:00
PHST- 2012/05/17 06:00 [entrez]
PHST- 2012/05/17 06:00 [pubmed]
PHST- 2012/09/18 06:00 [medline]
AID - 10.1021/jf3009603 [doi]
PST - ppublish
SO  - J Agric Food Chem. 2012 Jun 6;60(22):5532-9. doi: 10.1021/jf3009603. Epub 2012 
      May 25.