PMID- 22588209
OWN - NLM
STAT- MEDLINE
DCOM- 20130708
LR  - 20191210
IS  - 2047-2412 (Electronic)
IS  - 2047-2404 (Linking)
VI  - 14
IP  - 1
DP  - 2013 Jan
TI  - Validation of the isovolumetric relaxation time for the estimation of pulmonary 
      systolic arterial blood pressure in chronic pulmonary hypertension.
PG  - 51-5
LID - 10.1093/ehjci/jes093 [doi]
AB  - AIMS: Transthoracic echocardiography is a useful technique for non-invasive 
      detection of pulmonary arterial systolic pressure (PASP). Isovolumic relaxation 
      time (IVRT) measured by Doppler tissue imaging (DTI) is a sensitive measurement 
      of changes in pulmonary vasculature. Our aim was to validate IVRT in the 
      echocardiographic assessment of pulmonary hypertension (PH) patients. METHODS AND 
      RESULTS: We studied 196 PH patients (67% women, mean age 51.8 +/- 16.6 years, mean 
      PASP: 81 +/- 24 mmHg) and 37 consecutive age- and sex-matched controls (58% women, 
      mean age 44.7 +/- 16.4 years, mean PASP 27.7 +/- 5.5 mmHg). The estimation of PASP 
      was derived from tricuspid regurgitation velocity according to the Bernoulli 
      equation. The measurement of IVRT was calculated using pulsed tissue Doppler. In 
      the PH group and in the healthy volunteers group (P < 0.0001), the average IVRT 
      was 113.4 +/- 28.5 ms [95% confidence interval (CI): 109-117] and 41 +/- 12.5 ms (95% 
      CI: 37-45), respectively. We found a strong correlation between IVRT and systolic 
      pulmonary pressure in the PH group (r = 0.52, P < 0.0001) and a cut-off of 75 ms 
      showed a sensitivity and specificity of 94% and 97%, respectively, for the 
      prediction of elevated PASP. CONCLUSION: The determination of IVRT by DTI is a 
      simple and reproducible method that correlates well with PASP. It is, therefore, 
      a parameter to consider in the echocardiographic assessment of patients with PH, 
      and may be particularly important when the tricuspid Doppler signal is poor.
FAU - Zimbarra Cabrita, Ines
AU  - Zimbarra Cabrita I
AD  - Department of Cardiovascular Sciences, Hammersmith Hospital, Imperial College NHS 
      Trust, Du Cane Road, London W12 0HS, UK. ines.cabrita05@imperial.ac.uk
FAU - Ruisanchez, Cristina
AU  - Ruisanchez C
FAU - Grapsa, Julia
AU  - Grapsa J
FAU - Dawson, David
AU  - Dawson D
FAU - North, Bernard
AU  - North B
FAU - Pinto, Fausto J
AU  - Pinto FJ
FAU - Gibbs, J Simon R
AU  - Gibbs JS
FAU - Nihoyannopoulos, Petros
AU  - Nihoyannopoulos P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Validation Study
DEP - 20120515
PL  - England
TA  - Eur Heart J Cardiovasc Imaging
JT  - European heart journal. Cardiovascular Imaging
JID - 101573788
SB  - IM
MH  - Adult
MH  - Aged
MH  - Algorithms
MH  - Blood Pressure
MH  - Case-Control Studies
MH  - Chronic Disease
MH  - *Echocardiography, Doppler/methods
MH  - Echocardiography, Doppler, Pulsed
MH  - Female
MH  - Humans
MH  - Hypertension, Pulmonary/*diagnostic imaging/*physiopathology
MH  - Lung/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Myocardial Contraction
MH  - Predictive Value of Tests
MH  - Pulmonary Artery/diagnostic imaging/*physiopathology
MH  - Pulmonary Wedge Pressure
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Stroke Volume
MH  - Tricuspid Valve/physiopathology
MH  - *Ventricular Function, Right
EDAT- 2012/05/17 06:00
MHDA- 2013/07/09 06:00
CRDT- 2012/05/17 06:00
PHST- 2012/05/17 06:00 [entrez]
PHST- 2012/05/17 06:00 [pubmed]
PHST- 2013/07/09 06:00 [medline]
AID - jes093 [pii]
AID - 10.1093/ehjci/jes093 [doi]
PST - ppublish
SO  - Eur Heart J Cardiovasc Imaging. 2013 Jan;14(1):51-5. doi: 10.1093/ehjci/jes093. 
      Epub 2012 May 15.