PMID- 22588558
OWN - NLM
STAT- MEDLINE
DCOM- 20120807
LR  - 20211021
IS  - 1532-1827 (Electronic)
IS  - 0007-0920 (Print)
IS  - 0007-0920 (Linking)
VI  - 106
IP  - 12
DP  - 2012 Jun 5
TI  - c-Myc and EBV-LMP1: two opposing regulators of the HLA class I antigen 
      presentation machinery in epithelial cells.
PG  - 1980-8
LID - 10.1038/bjc.2012.197 [doi]
AB  - BACKGROUND: Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) 
      up-regulates the human leukocyte antigen (HLA) class I antigen presentation 
      machinery (APM). This appears counterintuitive with immune evasion in 
      EBV-associated tumours like nasopharyngeal carcinoma (NPC). METHODS: Latent 
      membrane protein 1-transfected epithelial cell lines were used as a model system 
      to study the impact of LMP1 and c-Myc on HLA class I components. The expression 
      of components of the HLA class I APM, c-Myc and Ki-67 was analysed in LMP1+ and 
      LMP1- NPC by immunohistochemistry. RESULTS: In epithelial cells, LMP1 
      up-regulated HLA class I APM. This effect could be counteracted by c-Myc, which 
      itself was up-regulated by LMP1 apparently through IL6 induction and Jak3/STAT3 
      activation. Studies of NPC biopsies revealed down-regulation of HLA class I APM 
      expression. No difference was observed between LMP1+ and LMP1- NPC. However, 
      expression of Ki-67 and c-Myc were up-regulated in LMP1+ tumours. CONCLUSION: 
      These findings raise the possibility that c-Myc activation in NPC might 
      antagonise the effect of LMP1 on HLA class I expression thus contributing to 
      immune escape of tumour cells.
FAU - Tudor, C S
AU  - Tudor CS
AD  - Institute of Pathology, Department of Nephropathology, 
      Friedrich-Alexander-University, Erlangen-Nuremberg, Germany. 
      Silke.Tudor@uk-erlangen.de
FAU - Dawson, C W
AU  - Dawson CW
FAU - Eckhardt, J
AU  - Eckhardt J
FAU - Niedobitek, G
AU  - Niedobitek G
FAU - Buttner, A C
AU  - Buttner AC
FAU - Seliger, B
AU  - Seliger B
FAU - Hartmann, A
AU  - Hartmann A
FAU - Buettner, M
AU  - Buettner M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120515
PL  - England
TA  - Br J Cancer
JT  - British journal of cancer
JID - 0370635
RN  - 0 (EBV-associated membrane antigen, Epstein-Barr virus)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Interleukin-6)
RN  - 0 (MYC protein, human)
RN  - 0 (Proto-Oncogene Proteins c-myc)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (STAT3 protein, human)
RN  - 0 (Viral Matrix Proteins)
SB  - IM
MH  - Antigen Presentation/*genetics
MH  - Carcinoma
MH  - Cell Line, Tumor
MH  - Epithelial Cells/immunology
MH  - Histocompatibility Antigens Class I/*metabolism
MH  - Humans
MH  - Interleukin-6/metabolism
MH  - Nasopharyngeal Carcinoma
MH  - Nasopharyngeal Neoplasms/*genetics
MH  - Proto-Oncogene Proteins c-myc/*metabolism
MH  - STAT3 Transcription Factor/metabolism
MH  - Signal Transduction
MH  - Up-Regulation
MH  - Viral Matrix Proteins/*metabolism
PMC - PMC3388564
EDAT- 2012/05/17 06:00
MHDA- 2012/08/08 06:00
PMCR- 2013/06/05
CRDT- 2012/05/17 06:00
PHST- 2012/05/17 06:00 [entrez]
PHST- 2012/05/17 06:00 [pubmed]
PHST- 2012/08/08 06:00 [medline]
PHST- 2013/06/05 00:00 [pmc-release]
AID - bjc2012197 [pii]
AID - 10.1038/bjc.2012.197 [doi]
PST - ppublish
SO  - Br J Cancer. 2012 Jun 5;106(12):1980-8. doi: 10.1038/bjc.2012.197. Epub 2012 May 
      15.