PMID- 22588842
OWN - NLM
STAT- MEDLINE
DCOM- 20130213
LR  - 20220309
IS  - 1861-0692 (Electronic)
IS  - 1861-0684 (Linking)
VI  - 101
IP  - 10
DP  - 2012 Oct
TI  - Adverse effects of permanent atrial fibrillation on heart failure in patients 
      with preserved left ventricular function and chronic right apical pacing for 
      complete heart block.
PG  - 829-36
AB  - BACKGROUND: The impact of atrial fibrillation (AF) on heart failure (HF) was 
      evaluated in patients with preserved left ventricular (LV) function and long-term 
      right ventricular (RV) pacing for complete heart block. METHODS: Clinical, 
      echocardiographic, and laboratory parameters of HF were assessed in 35 patients 
      with established AF who had undergone ablation of the atrioventricular node and 
      pacemaker implantation (Group A) and 31 patients who received dual-chamber pacing 
      for spontaneous complete heart block (Group B). RESULTS: During a follow-up 
      period of 12.7 +/- 7.5 years, New York Heart Association (NYHA) functional class 
      increased from 1.3 +/- 0.5 to 2.1 +/- 0.6 (p < 0.0001) in Group A, and from 1.3 +/- 0.4 
      to 1.6 +/- 0.7 (p < 0.01) in Group B. Left ventricular ejection fraction (LVEF) 
      decreased from 59.7 +/- 5.1 to 53.0 +/- 8.2 (p < 0.0001) in Group A, but remained 
      stable (58.6 +/- 4.2 vs. 56.9 +/- 7.0 %, p = 0,21) in Group B. At the end of 
      follow-up, markers of LV function were moderately depressed in Group A compared 
      with those in Group B: NYHA class 2.1 +/- 0.6 versus 1.6 +/- 0.7, p = 0.001; LVEF 
      53.0 +/- 8.2 versus 56.9 +/- 7.0 %, p < 0.05; LV diastolic diameter 53.6 +/- 5.8 mm 
      versus 50.7 +/- 4.9 mm, p < 0.05; N-terminal pro-brain natriuretic peptide 
      (NT-proBNP) 1116.8 +/- 883.9 versus 622.9 +/- 1059.4 pg/ml, p < 0.05. Progression of 
      paroxysmal AF to permanent AF during follow-up was common, while new onset of AF 
      was rare. Permanent AF was an independent predictor of declining LVEF >10 %, 
      increasing NYHA class >/=1, and NT-proBNP levels >1,000 pg/ml. CONCLUSIONS: 
      Permanent AF was associated with adverse effects on LV function and symptoms of 
      HF in patients with long-term RV pacing for complete heart block, and appears to 
      play an important role in the development of HF in this specific patient cohort.
FAU - Lampe, Brigitte
AU  - Lampe B
AD  - Department of Cardiology, University of Bonn, Bonn, Germany.
FAU - Hammerstingl, Christoph
AU  - Hammerstingl C
FAU - Schwab, Jorg Otto
AU  - Schwab JO
FAU - Mellert, Fritz
AU  - Mellert F
FAU - Stoffel-Wagner, Birgit
AU  - Stoffel-Wagner B
FAU - Grigull, Andreas
AU  - Grigull A
FAU - Fimmers, Rolf
AU  - Fimmers R
FAU - Maisch, Bernhard
AU  - Maisch B
FAU - Nickenig, Georg
AU  - Nickenig G
FAU - Lewalter, Thorsten
AU  - Lewalter T
FAU - Yang, Alexander
AU  - Yang A
LA  - eng
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20120516
PL  - Germany
TA  - Clin Res Cardiol
JT  - Clinical research in cardiology : official journal of the German Cardiac Society
JID - 101264123
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Atrial Fibrillation/complications/*physiopathology
MH  - Cardiac Pacing, Artificial/*methods
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Block/physiopathology/*therapy
MH  - Heart Failure/etiology/*physiopathology
MH  - Heart Ventricles
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Ventricular Dysfunction, Left/etiology/physiopathology
MH  - Ventricular Function, Left
EDAT- 2012/05/17 06:00
MHDA- 2013/02/14 06:00
CRDT- 2012/05/17 06:00
PHST- 2012/01/07 00:00 [received]
PHST- 2012/04/26 00:00 [accepted]
PHST- 2012/05/17 06:00 [entrez]
PHST- 2012/05/17 06:00 [pubmed]
PHST- 2013/02/14 06:00 [medline]
AID - 10.1007/s00392-012-0468-7 [doi]
PST - ppublish
SO  - Clin Res Cardiol. 2012 Oct;101(10):829-36. doi: 10.1007/s00392-012-0468-7. Epub 
      2012 May 16.