PMID- 22591724
OWN - NLM
STAT- MEDLINE
DCOM- 20121207
LR  - 20220316
IS  - 1878-4046 (Electronic)
IS  - 1076-6332 (Linking)
VI  - 19
IP  - 8
DP  - 2012 Aug
TI  - Hyperpolarized 129Xe magnetic resonance imaging: tolerability in healthy 
      volunteers and subjects with pulmonary disease.
PG  - 941-51
LID - 10.1016/j.acra.2012.03.018 [doi]
AB  - RATIONALE AND OBJECTIVES: The objective of this study was to evaluate the 
      tolerability of hyperpolarized (129)Xe gas inhaled from functional residual 
      capacity and magnetic resonance imaging in healthy subjects and those with 
      pulmonary disease. MATERIALS AND METHODS: Twelve healthy volunteers (mean age, 59 
      +/- 17 years), seven subjects with asthma (mean age, 47 +/- 7 years), 10 subjects 
      with chronic obstructive pulmonary disease (mean age, 74 +/- 4 years), three 
      subjects with cystic fibrosis (mean age, 27 +/- 10 years), and a single subject 
      with radiation-induced lung injury (age, 66 years) were enrolled and evaluated 
      over 43 visits with 136 anoxic inhalations of 500 mL (129)Xe gas mixed with 500 
      mL (4)He gas. Oxygen saturation and heart rate were monitored during the 
      breath-hold and imaging; subjects were queried for adverse events (AEs) before 
      and immediately following gas inhalation and for 24 hours after the last dose. 
      RESULTS: No subjects withdrew from the study or reported serious, hypoxic, or 
      severe AEs. Over the course of 136 dose administrations, two mild AEs (1%) were 
      reported in two different subjects (two of 33 [6%]). One of these AEs 
      (light-headedness) was temporally related and judged as possibly related to 
      (129)Xe administration and resolved without treatment within 2 minutes. 
      Statistically significant but clinically insignificant changes in oxygen 
      saturation and heart rate were observed after inhalation (P < .001), and both 
      resolved 1 minute later, with no difference between subject groups. CONCLUSIONS: 
      Inhalation of hyperpolarized (129)Xe gas and subsequent magnetic resonance 
      imaging were well tolerated in healthy subjects and ambulatory subjects with 
      obstructive and restrictive pulmonary disease.
CI  - Copyright (c) 2012 AUR. Published by Elsevier Inc. All rights reserved.
FAU - Shukla, Yajur
AU  - Shukla Y
AD  - Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada.
FAU - Wheatley, Andrew
AU  - Wheatley A
FAU - Kirby, Miranda
AU  - Kirby M
FAU - Svenningsen, Sarah
AU  - Svenningsen S
FAU - Farag, Adam
AU  - Farag A
FAU - Santyr, Giles E
AU  - Santyr GE
FAU - Paterson, Nigel A M
AU  - Paterson NA
FAU - McCormack, David G
AU  - McCormack DG
FAU - Parraga, Grace
AU  - Parraga G
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120515
PL  - United States
TA  - Acad Radiol
JT  - Academic radiology
JID - 9440159
RN  - 0 (Contrast Media)
RN  - 0 (Xenon Isotopes)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Contrast Media/*adverse effects
MH  - Female
MH  - Humans
MH  - Lung Diseases/*diagnosis
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Xenon Isotopes/*adverse effects
MH  - Young Adult
EDAT- 2012/05/18 06:00
MHDA- 2012/12/12 06:00
CRDT- 2012/05/18 06:00
PHST- 2012/02/17 00:00 [received]
PHST- 2012/03/27 00:00 [revised]
PHST- 2012/03/29 00:00 [accepted]
PHST- 2012/05/18 06:00 [entrez]
PHST- 2012/05/18 06:00 [pubmed]
PHST- 2012/12/12 06:00 [medline]
AID - S1076-6332(12)00170-5 [pii]
AID - 10.1016/j.acra.2012.03.018 [doi]
PST - ppublish
SO  - Acad Radiol. 2012 Aug;19(8):941-51. doi: 10.1016/j.acra.2012.03.018. Epub 2012 
      May 15.