PMID- 22593232
OWN - NLM
STAT- MEDLINE
DCOM- 20130419
LR  - 20130516
IS  - 1938-2723 (Electronic)
IS  - 1076-0296 (Linking)
VI  - 18
IP  - 6
DP  - 2012 Nov
TI  - Tumor necrosis factor-alpha gene polymorphisms in FMF and their association with 
      amyloidosis.
PG  - 633-7
LID - 10.1177/1076029611432743 [doi]
AB  - Familial Mediterranean fever (FMF) is an autosomal recessive disorder 
      characterized by periodic provocative attacks of fever with peritonitis, 
      pleuritis, arthritis, or eriseplemya. Tumor necrosis factor-alpha (TNF-alpha) plays an 
      important role in the regulation of the immune response as a part of the cytokine 
      network, including activation of macrophages and apoptosis. We investigated the 
      possible association of TNF-alpha promoter -1031T/C and -308G/A polymorphisms in 86 
      FMF patients carrying M694 V homozygous mutation and 100 matched healthy controls 
      both from Iranian Azeri Turks. Our data showed that patients with TNF-alpha -308 GG 
      are more susceptible to the development of amyloidosis and arthritis (P value 
      <.05). These data also showed that the frequency of TNF-alpha -308 A allele is 
      considerably low among patients with amyloidosis, and it may have protective role 
      among them (odds ratio [OR] = 0.083, chi(2) = 5.46, P value = .003). Further 
      evaluation of this polymorphism may be important and need further studies.
FAU - Bonyadi, Mortaza
AU  - Bonyadi M
AD  - Center of Excellence for Biodiversity, University of Tabriz, Tabriz, Iran. 
      jabbarpour@tabrizu.ac.ir
FAU - Bahrami, Salahadin
AU  - Bahrami S
FAU - Jahanafrooz, Zohreh
AU  - Jahanafrooz Z
FAU - Dastgiri, Saeed
AU  - Dastgiri S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120515
PL  - United States
TA  - Clin Appl Thromb Hemost
JT  - Clinical and applied thrombosis/hemostasis : official journal of the 
      International Academy of Clinical and Applied Thrombosis/Hemostasis
JID - 9508125
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Amyloidosis/complications/ethnology/*genetics
MH  - Arthritis/complications/ethnology/genetics
MH  - Case-Control Studies
MH  - Familial Mediterranean Fever/complications/ethnology/*genetics
MH  - Female
MH  - Humans
MH  - Iran/ethnology
MH  - Male
MH  - *Point Mutation
MH  - *Polymorphism, Single Nucleotide
MH  - *Promoter Regions, Genetic
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2012/05/18 06:00
MHDA- 2013/04/23 06:00
CRDT- 2012/05/18 06:00
PHST- 2012/05/18 06:00 [entrez]
PHST- 2012/05/18 06:00 [pubmed]
PHST- 2013/04/23 06:00 [medline]
AID - 1076029611432743 [pii]
AID - 10.1177/1076029611432743 [doi]
PST - ppublish
SO  - Clin Appl Thromb Hemost. 2012 Nov;18(6):633-7. doi: 10.1177/1076029611432743. 
      Epub 2012 May 15.