PMID- 22594266
OWN - NLM
STAT- MEDLINE
DCOM- 20120717
LR  - 20120518
IS  - 0001-6837 (Print)
IS  - 0001-6837 (Linking)
VI  - 69
IP  - 3
DP  - 2012 May-Jun
TI  - Preparation and characterization of floating drug delivery system of 
      azithromycin.
PG  - 515-22
AB  - The objective of present study was to develop a stomach drug delivery system of 
      azithromycin (AZH) as a model drug for eradication of Helicobacter pyloni (H. 
      pylori). Floating microspheres of AZH were prepared by the solvent evaporation 
      method. The prepared microspheres were subjected to evaluation for particle size, 
      incorporation efficiency, in vitro buoyancy and in vitro drug release 
      characteristics. The formulations were prepared at a variable stirring rate (300 
      to 500 rpm) and temperature (30-50 degrees C). Surface morphology characteristics 
      were studied using scanning electron microscopy (SEM). The mean particle size of 
      the microspheres significantly increased with increasing polymer concentration 
      and was in the range 252.26 +/- 6.50 to 380.91 +/- 4.59 microm. Angle of repose 
      was between 26.42 to 35.83 degrees. Tapped density ranged between 0.493 to 0.612 
      g/cm3. The compressibility index of all formulations was found to be in the range 
      of 12.41 to 17.16%, which was < 20 indicating good flow characteristics. The 
      encapsulation efficiency of the prepared microspheres was in the range of 27.8 
      +/- 4.30 to 66.23 +/- 2.08%. The physical state of the drug, before and after 
      formulation was determined by differential scanning calorimetry (DSC). Percentage 
      buoyancy of the microspheres was in the range 45.52 +/- 0.69 to 68.71 +/- 0.61% 
      for 8 h. In vitro drug release studies were performed in simulated 
      gastrointestinal fluid (SGF), pH 2.0 as dissolution medium (900 mL) for 8 h. 
      Effects of stirring rate during preparation, polymer concentration and 
      temperature on the size of microspheres and drug release were also observed. The 
      results of the present studies indicated that the floating microspheres of AZH 
      were formulated to provide site specific delivery of drug with a view to provide 
      an effective and safe therapy for eradication of H. pylori with a reduced dose 
      and reduced duration of therapy.
FAU - Wasnik, Shailendra
AU  - Wasnik S
AD  - SLT Institute of Pharmaceutical Sciences, Guru Ghasidas University, Bilaspur - 
      495 009 (C.G.), India. shailendra.wasnik@gmail.com
FAU - Parmar, Poonam
AU  - Parmar P
FAU - Singh, Deepika
AU  - Singh D
FAU - Ram, Alpana
AU  - Ram A
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Acta Pol Pharm
JT  - Acta poloniae pharmaceutica
JID - 2985167R
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Drug Carriers)
RN  - 0 (Polymers)
RN  - 83905-01-5 (Azithromycin)
SB  - IM
MH  - Anti-Bacterial Agents/administration & dosage/chemistry
MH  - Azithromycin/*administration & dosage/*chemistry
MH  - Chemistry, Pharmaceutical
MH  - Drug Carriers/chemistry
MH  - Drug Delivery Systems/methods
MH  - Helicobacter pylori/drug effects
MH  - Microspheres
MH  - Particle Size
MH  - Polymers/chemistry
MH  - Temperature
EDAT- 2012/05/19 06:00
MHDA- 2012/07/18 06:00
CRDT- 2012/05/19 06:00
PHST- 2012/05/19 06:00 [entrez]
PHST- 2012/05/19 06:00 [pubmed]
PHST- 2012/07/18 06:00 [medline]
PST - ppublish
SO  - Acta Pol Pharm. 2012 May-Jun;69(3):515-22.