PMID- 22594783
OWN - NLM
STAT- MEDLINE
DCOM- 20121218
LR  - 20211021
IS  - 1471-2350 (Electronic)
IS  - 1471-2350 (Linking)
VI  - 13
DP  - 2012 May 17
TI  - The MAP2K5-linked SNP rs2241423 is associated with BMI and obesity in two cohorts 
      of Swedish and Greek children.
PG  - 36
AB  - BACKGROUND: Recent genome-wide association studies have identified a single 
      nucleotide polymorphism within the last intron of MAP2K5 associated with a higher 
      body mass index (BMI) in adults. MAP2K5 is a component of the MAPK-family 
      intracellular signaling pathways, responding to extracellular growth factors such 
      as brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF). In 
      this study, we examined the association of this variant in two cohorts of 
      children from Sweden and Greece. METHODS: We examine the association of rs2241423 
      to BMI in a cohort of 474 Swedish children admitted for treatment of childhood 
      obesity and 519 children matched for gender, ethnicity and socioeconomic 
      background from the Stockholm area, as well as a cross-sectional cohort of 2308 
      Greek school children (Healthy Growth Study). Children were genotyped using a 
      predesigned TaqMan polymorphism assay. Logistic regression was used to test for 
      an association of rs2241423 to obesity in the cohort of Swedish children. Linear 
      regression was used to test for an association of rs2241423 to BMI z-score and 
      phenotypic measurements of body adiposity in the cohort of Greek children. Models 
      were adjusted for age and gender. In the cohort of Greek children the model was 
      also adjusted for stage of pubertal development. RESULTS: The minor allele of 
      rs2241423, allele A, was associated with a protective effect against obesity in 
      the cohort of Swedish children (p = 0.029, OR = 0.79 (95% CI: 0.64-0.98)), and 
      with a lower BMI z-score in the cohort of Greek children (p = 0.028, beta = -0.092). 
      No association to phenotypic measurements of body fat distribution could be 
      observed in our study. CONCLUSIONS: rs2241423 was associated with BMI and obesity 
      in two independent European cohorts suggesting a role for MAP2K5 in early weight 
      regulation.
FAU - Rask-Andersen, Mathias
AU  - Rask-Andersen M
AD  - Department of Neuroscience, Functional Pharmacology, Uppsala University, BMC, 
      Uppsala SE 75124, Sweden.
FAU - Jacobsson, Josefin A
AU  - Jacobsson JA
FAU - Moschonis, George
AU  - Moschonis G
FAU - Ek, Anna E
AU  - Ek AE
FAU - Chrousos, George P
AU  - Chrousos GP
FAU - Marcus, Claude
AU  - Marcus C
FAU - Manios, Yannis
AU  - Manios Y
FAU - Fredriksson, Robert
AU  - Fredriksson R
FAU - Schioth, Helgi B
AU  - Schioth HB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120517
PL  - England
TA  - BMC Med Genet
JT  - BMC medical genetics
JID - 100968552
RN  - EC 2.7.12.2 (MAP Kinase Kinase 5)
RN  - EC 2.7.12.2 (MAP2K5 protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Body Mass Index
MH  - Case-Control Studies
MH  - Child
MH  - Cohort Studies
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Greece/epidemiology
MH  - Humans
MH  - Linkage Disequilibrium
MH  - MAP Kinase Kinase 5/*genetics
MH  - Male
MH  - Obesity/epidemiology/*genetics
MH  - Phenotype
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Prognosis
MH  - Risk Factors
MH  - Sweden/epidemiology
MH  - Young Adult
PMC - PMC3459804
EDAT- 2012/05/19 06:00
MHDA- 2012/12/19 06:00
PMCR- 2012/05/17
CRDT- 2012/05/19 06:00
PHST- 2012/01/24 00:00 [received]
PHST- 2012/05/04 00:00 [accepted]
PHST- 2012/05/19 06:00 [entrez]
PHST- 2012/05/19 06:00 [pubmed]
PHST- 2012/12/19 06:00 [medline]
PHST- 2012/05/17 00:00 [pmc-release]
AID - 1471-2350-13-36 [pii]
AID - 10.1186/1471-2350-13-36 [doi]
PST - epublish
SO  - BMC Med Genet. 2012 May 17;13:36. doi: 10.1186/1471-2350-13-36.