PMID- 22594815
OWN - NLM
STAT- MEDLINE
DCOM- 20120921
LR  - 20120518
IS  - 1464-0678 (Electronic)
IS  - 1357-650X (Linking)
VI  - 17
IP  - 3
DP  - 2012
TI  - A demonstration that task difficulty can confound the interpretation of lateral 
      differences in brain activation between typical and dyslexic readers.
PG  - 340-60
LID - 10.1080/1357650X.2011.577780 [doi]
AB  - Dyslexic readers (DRs) manifest atypical patterns of brain activity, which may be 
      attributed to aberrant neural connectivity and/or an attempt to activate 
      compensatory pathways. This paper evaluates whether differences in brain 
      activation patterns between DRs and typical readers (TRs) are confounded by task 
      difficulty. Eight DRs and eight TRs matched for age, sex, and nonverbal IQ 
      performed pseudoword rhyming tasks at two levels of difficulty during 
      magnetoencephalography. Task difficulty varied with the number of successive 
      target pseudowords presented before the test pseudoword. Regions of interest 
      were: the temporoparietal area (TPA), the ventral occipital temporal area (VOT), 
      and the inferior frontal gyrus (IFG). Activity was analysed for the 660-ms period 
      after test pseudoword onset. During the discrepant performance condition left 
      hemispheric TPA activation increased across time for TRs, but not DRs, and IFG 
      bihemispheric activation was greater in TRs by the end of the trial. During the 
      equivalent performance condition no group differences in TPA or IFG activation 
      were found. We argue that these results indicate that direct comparison of DR 
      versus TR brain activity is confounded when DRs are more challenged than TRs. 
      This highlights the importance of equating reading group performance during 
      neuroimaging of reading-related tasks.
FAU - Fisher, Janet McGraw
AU  - Fisher JM
AD  - Brain, Behavior, and Cognition Program, Boston University, Boston, MA 02215, USA.
FAU - Liederman, Jacqueline
AU  - Liederman J
FAU - Johnsen, Jami
AU  - Johnsen J
FAU - Lincoln, Alexis
AU  - Lincoln A
FAU - Frye, Richard
AU  - Frye R
LA  - eng
GR  - NS046565/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20111013
PL  - England
TA  - Laterality
JT  - Laterality
JID - 9609064
SB  - IM
MH  - Adult
MH  - Brain Mapping/methods/*psychology
MH  - Case-Control Studies
MH  - Cerebral Cortex/*physiopathology
MH  - Dyslexia/*physiopathology
MH  - Female
MH  - Functional Laterality/*physiology
MH  - Humans
MH  - Magnetic Resonance Imaging/methods/*psychology
MH  - Magnetoencephalography/methods/*psychology
MH  - Male
MH  - Photic Stimulation/methods
MH  - Psychomotor Performance/physiology
EDAT- 2012/05/19 06:00
MHDA- 2012/09/22 06:00
CRDT- 2012/05/19 06:00
PHST- 2012/05/19 06:00 [entrez]
PHST- 2012/05/19 06:00 [pubmed]
PHST- 2012/09/22 06:00 [medline]
AID - 10.1080/1357650X.2011.577780 [doi]
PST - ppublish
SO  - Laterality. 2012;17(3):340-60. doi: 10.1080/1357650X.2011.577780. Epub 2011 Oct 
      13.