PMID- 22595024
OWN - NLM
STAT- MEDLINE
DCOM- 20130124
LR  - 20181201
IS  - 1460-2202 (Electronic)
IS  - 0271-3683 (Linking)
VI  - 37
IP  - 10
DP  - 2012 Oct
TI  - Relation between total tear IgE and severity of acute seasonal allergic 
      conjunctivitis.
PG  - 864-70
LID - 10.3109/02713683.2012.689069 [doi]
AB  - PURPOSE: Measurement of total tear immunoglobulin E (IgE) is useful for the 
      diagnosis of allergic conjunctivitis, but it is still unknown whether measurement 
      of total tear IgE is useful for assessment of the severity of allergic 
      conjunctivitis. We evaluated the relation between the total IgE level in tears 
      and objective signs of allergic conjunctivitis. METHODS: A prospective, 
      nonrandomized, and cross-sectional study was conducted in 84 patients with 
      allergic conjunctivitis (allergic group) and 80 age- and sex-matched healthy 
      control subjects (control group). The total tear IgE score was obtained with the 
      Allerwatch((R)) test (0, 1, and 2), and ten severity scores (0, 1, 2, 3) were 
      determined for objective ocular findings of the palpebral and bulbar conjunctiva, 
      as well as limbal and corneal lesions. RESULTS: The scores for total tear IgE and 
      each of the objective ocular findings were higher in the allergic group than in 
      the control group (all p < 0.01). The total tear IgE score was correlated with 
      the severity of each clinical feature of allergic conjunctivitis (p < 0.01), 
      except for corneal epithelial damage in the allergic group. Multivariate analysis 
      revealed that the severity of giant papillae was the most important indicator of 
      the total tear IgE score (odds ratio = 1.33, p < 0.00001). CONCLUSION: The total 
      tear IgE score was correlated with the scores for objective signs of allergic 
      conjunctivitis. This rapid test for total IgE in tear fluid is easy to perform 
      and could be used to assess the severity of allergic conjunctivitis on an 
      outpatient basis.
FAU - Mimura, Tatsuya
AU  - Mimura T
AD  - Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 
      Tokyo, Japan. mimurat-tky@umin.ac.jp
FAU - Usui, Tomohiko
AU  - Usui T
FAU - Yamagami, Satoru
AU  - Yamagami S
FAU - Miyai, Takashi
AU  - Miyai T
FAU - Amano, Shiro
AU  - Amano S
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120517
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Chromatography, Affinity/*methods
MH  - Conjunctivitis, Allergic/*diagnosis/*immunology
MH  - Cross-Sectional Studies
MH  - *Diagnostic Techniques, Ophthalmological
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/immunology/*metabolism
MH  - Male
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Seasons
MH  - Severity of Illness Index
MH  - Tears/*immunology
MH  - Young Adult
EDAT- 2012/05/19 06:00
MHDA- 2013/01/25 06:00
CRDT- 2012/05/19 06:00
PHST- 2012/05/19 06:00 [entrez]
PHST- 2012/05/19 06:00 [pubmed]
PHST- 2013/01/25 06:00 [medline]
AID - 10.3109/02713683.2012.689069 [doi]
PST - ppublish
SO  - Curr Eye Res. 2012 Oct;37(10):864-70. doi: 10.3109/02713683.2012.689069. Epub 
      2012 May 17.